NEW INSIGHTS INTO MOLECULAR BASIS OF GLIOBLASTOMA MULTIFORME AND ASSOCIATED IMMUNOSUPPRESSION
Journal Title: Acta Facultatis Medicae Naissensis - Year 2013, Vol 30, Issue 0
Abstract
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in adults and carries the poorest prognosis despite aggressive multimodal therapy. The majority of GBMs develop de novo (primary) with a short clinical history, while secondary GBMs develop through progression from preexisting lower-grade precursor gliomas and show distinct genetic and expression profiles including the high frequency of isocitrate dehydrogenase 1 (IDH1) mutations, already present in precursor lesions. Large-scale integrative genomic studies provided the new view that GBMs are remarkable molecularly heterogeneous tumors and identified distinct molecular entities that may lead to different therapeutic approaches. Although being restricted to the intracranial compartment, GBMs are associated with global immunosuppression. Better understanding of the immune response to GBMs growing in the immunologically distinct microenvironment in the brain and mechanisms by which they may escape the response and even suppress it will accelerate the development of more effective immunotherapies. This review summarizes the current knowledge regarding genetic alterations and signaling pathways critical to the biology of GBMs, few mechanisms of developing local and systemic GBM-induced immunosuppression, and the role of GBM stem cells.
Authors and Affiliations
Irena Dimov, Desanka Tasic, Ivan Stefanović, Dragan Dimov
Keywords
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- EP ID EP136524
- DOI 10.2478/afmnai-2013-0009
- Views 114
- Downloads 0
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