Newly developed method for determination Indomethacin using Phosphotungstic acid by continue flow injection analysis via homemade ISNAG-fluorimeter.
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 2
Abstract
A new, simple, sensitive and fastdeveloped methodfor the determination of Indomethacinin pure form and drugs (tablets)by continuous flow injection diverged light. The method based on the reaction of the Indomethacin with Phosphotungstic acid to formoff-white precipitate, using homemade ISNAG- fluorimeter. Optimum parameter have been studied to increase the sensitivity for developed method. The linear dynamic range for the instrument response versus Indomethacinconcentration was 0.01- 5mmol/L while the L.O.D was 320.222ng/sample from the step wise dilution for the minimum concentration of lowest concentration in the linear dynamic range of the calibration graph. The correlation coefficient (r) was 0.9952while percentage linearity (R2%) was 99.05%. RSD% for the repeatability (n=7) was lower than 0.5% for the determination of Indomethacin, with concentration of 1, 5mmol/L respectively. The methods: developed method was applied successfully for the determination of Indomethacinin pharmaceutical tablets. A comparison was made between the newly developed method with the classical method (uv-spectrophotometer method) of analysis using the standard addition method via the use of paired t-test. It shows that there was no significant difference between the quoted values of each individual company with calculated t-value at 95% confidence interval from developed method.
Authors and Affiliations
Proph. Nagam Shakir. Turkie, Hussein Fares Abd- Alrazack
Keywords
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- EP ID EP413967
- DOI 10.9790/5736-1102012539.
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