Non-alcoholic fatial diseases of the liver: historical aspect of the formation of nosological unit, etiology and pathogenetic peculiarities of this pathology (literature review)
Journal Title: Бюллетень науки и практики - Year 2018, Vol 4, Issue 12
Abstract
This literature review focuses on non-alcoholic fatty liver disease (NAFTLD). Today, the world practice of researching diseases is characterized by a multifactor approach, in particular, it concerns pathologies, which are based on a cascade of metabolic disorders, where insulin resistance is one of the key places. Today, NAFTLD is considered an integral part of the metabolic syndrome. The frequency of occurrence of NAFTLD varies from 14 to 26%, in addition, 10% of patients show signs of steatohepatitis non-alcoholic etiology. The pathogenesis of steatosis and metabolic steatohepatitis is poorly studied and there are very contradictory data in the literature, which served as the basis for the creation of this review. The authors consider in detail the historical aspect of the formation of the NAFTLD as an independent nosological unit. A number of etiological aspects of the formation of NAFTLD, but to a large extent, the review is devoted to the mechanisms and pathogenesis of the formation of NAFTLD. A concept has been put forward that reflects the role of oxidative stress and the death of mitochondrial complexes in initiating the initiation of apoptosis and/or necrosis of hepatocytes (under these conditions there is an activation of leukocytes and Ito cells in Disse space, which contributes to the fibrosis proliferation and the formation of NAFTLD). Also, in this paper, there is also a place for searching for the cause-and-effect relationships of such comorbid diseases, such as NAFTLD and carbohydrate metabolism disorders.
Authors and Affiliations
L. Mosina, Denis Korobkov, Ekaterina Mokina, Daria Kumanyaeva, M. Rakhmatullina
Keywords
Related Articles
- EP ID EP497447
- DOI 10.5281/zenodo.2256509
- Views 79
- Downloads 0
The value of breast-feeding on the formation of the psychomotor development of children of early age
Psychomotor development of children depending on the type of feeding is estimated. 255 young children of different types of feeding were examined. Psychomotor development (sensory development, General motor activity, man...
Implementation of international safety rules on radioactive waste management in national law of Kyrgyz Republic
The article provides an overview of the implementation of the requirements of the Joint Convention on the Safety of Spent Fuel Management and on the Safety of Radioactive Waste Management of September 5, 1997 in the nati...
Exploration of psychoemotional state of medical students of Kyrgyz-Russian Slavic University
The dependence between progress in studies students of the school of medicine and their psychoemotional state was investigated in this exploration. The psychoemotional trends in medical student’s population were explored...
Macrostructural level of the soil resources management (as an example of Lankaran Lowland)
The article presents a description of three hierarchical–structural levels of soil resources management using the example of the Lenkoran Lowland (macro, meso and microstructures). The first level is management at the ma...
The evolution of the institutional conditions for ensuring socio-economic security
Shvaiba D.