Non-epilepsy uses of antiepilepsy drugs.
Journal Title: Pharmacological Reports - Year 2006, Vol 58, Issue 1
Abstract
Antiepileptic drugs (AEDs) affect various neurotransmitters (i.e. GABA, glutamate), receptors (i.e. GABAergic, glutamatergic), and ion channels (i.e. for sodium or calcium) which is responsible for their anticonvulsant activity. However, this broad spectrum of action may bealso utilized in other pathological conditions. For example, both conventional and newer AEDs may be used in patients suffering from neuropathic pain, migraine, essential tremor, spasticity, restless legssyndrome and a number of psychiatric disorders (f.e. bipolar disease or schizophrenia). Also, isolateddata point to their potential use in Parkinson's or Alzheimer's disease. There is experimental backgroundindicating a potent neuroprotective efficacy of AEDs in numerous models of brain ischemia. However, the clinical data are very limited and this problem requires careful assessment.
Authors and Affiliations
Paweł Zaremba, Magdalena Białek, Barbara Błaszczyk, Piotr Cioczek, Stanisław Czuczwar
Keywords
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