Non-Exercise Estimated Cardiorespiratory Fitness and All-Cause Mortality in Cancer Patients
Journal Title: Journal of Clinical Medical Research - Year 2024, Vol 5, Issue 1
Abstract
Background: The purpose of the present study was to examine the association between non-exercise Cardiorespiratory Fitness (eCRF) and all-cause mortality in cancer patients. Methods and Findings: A total of 2,404 participants from the Aerobics Center Longitudinal Study (622 women and 1,782 men) with a cancer diagnosis were followed for mortality. Non-exercise eCRF was calculated in Metabolic Equivalents (METs) with sex-specific algorithms at baseline. Multivariable Cox regression models were used to examine the association between CRF and risk of all-cause mortality. Hazard ratios and 95% confidence intervals were calculated as an index of strength of the association. More than 96% (2,323) of the 2,404 participants survived, while 81 (3.4%) died. In the multivariable adjusted model, each 1-MET increment was associated with a 17% decreased risk of all-cause mortality. Compared with the reference group, those in the middle CRF group had a 58% lower risk of death and those in the upper CRF group had a 78% lower risk of death than those in the lower CRF group (Ptrend=0.0002). Conclusion: CRF estimated using a non-exercise formula (non-exercise eCRF) is inversely associated with all-cause mortality in cancer patients.
Authors and Affiliations
John Higgins, Jiajia Zhang, Carl J Lavie, Xuemei Sui
Keywords
Related Articles
- EP ID EP735192
- DOI https://doi.org/10.46889/JCMR.2024.5201
- Views 41
- Downloads 0
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