Nuclear Morphometric Analysis in Fine Needle Aspirates of Breast Neoplasms
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2018, Vol 7, Issue 11
Abstract
Background: Fine needle aspiration cytology (FNAC) is applied as the primary tool for the diagnosis in breast masses because of its ease and rapidity. However, it is a largely subjective tool. The morphological overlap among the sequential lesions from the precancerous group to frank carcinoma further cause “gray zone” in cytology, estimated to constitute 8.9%. Morphometry is the measurement of cell parameters microscopically by image analysis. The present study has been undertaken to evaluate role of nuclear morphometry in benign and malignant breast neoplasms. Aim: To classify breast lumps according to guidelines given by UK National Health Service Breast Screening Program (NHSBSP) and to compare the nuclear morphometry among those categories. Setting and design: A retrospective-prospective study. Material and Methods: Cases with palpable breast lumps were evaluated by FNAC and were cytologically classified according to UKNHSBSP guidelines. Nuclear Morphometric parameters: nuclear area, perimeter, long and short axis and diameter were studied and compared within the various categories. Statistical Analysis used: Student’s t test was used as the test of significance. Result: Mean age was 37.7 years. 47.3% cases belonged to Category C2 (benign), 6.8% cases to Category C3 (atypia probably benign), 17.6% cases Category C4 (suspicious of malignancy) and 27% belonged to Category C5 (malignant). The nuclear morphometric parameters including nuclear area, perimeter, short axis, long axis and diameter were found to be statistically significant (p<0.05) in differentiating between benign and malignant categories. Conclusion: Nuclear morphometry serves as a valuable method in distinguishing benign and malignant breast aspirates and also correlates well with the cytological categories.
Authors and Affiliations
Arunima Singhal
Keywords
Related Articles
- EP ID EP530029
- DOI 10.21088/ijprp.2278.148X.71118.5
- Views 72
- Downloads 0
Clinicopathological Study of Tuberculous Lesions of Small and Large Intestine (Including Appendix
Background: Tuberculosis in India continues to be a major health problem with approximately one eight of total cases being extra pulmonary. The gastrointestinal tract is involved in 66-75% of cases of abdominal tuberculo...
A Study of Platelet Count and Platelet Indices in Neonatal Sepsis
Introduction: Neonatal sepsis has always been a significant health problem worldwide, especially in developing countries. Since it is a treatable condition, it has to be diagnosed at the earliest to initiate treatment an...
Smog
not available
Cytohistopathological Study of Benign Breast Lesions: An Institutional Experience
Introduction: Cytomorphologic features of benign breast lesions which encompasses majority of palpable breast lesions have not been studied in great detail. Aim and objective: To study the cytomorphological aspects of be...
Histopathological Spectrum of Breast Lumps: A One Year Retrospective Study
Introduction: In India, breast carcinoma is the second most common cause of death in women next only to cervical cancer and the incidence is as high as 20 per 1,00,000 women. The benign lesions are most common in the fir...