Obesity, endocrine disruption and male infertility
Journal Title: Asian Pacific Journal of Reproduction - Year 2019, Vol 5, Issue 8
Abstract
Obesity has become a global pandemic since the last few decades with prevalence in more than one-third of the population in the United States. Another concurrent global health concern is the declining trend in male fecundity in terms of semen quality. Male infertility etiology is multifactorial with obesity serving as one of the major causatives. An array of research is directed in unveiling the potential mechanism underlying the obesity-induced male subfertility or infertility. Obesity may alter the hormonal milieu of the hypothalamic- pituitary-gonadal axis, its crosstalks with other metabolic hormones, upregulates secretion of adipose tissue-derived hormones and other factors, thus influencing the endocrine regulation of male reproduction. Obesity may also directly impair testicular functions by inducing genetic and epigenetic alterations in spermatozoa, disrupting sperm morphology and functions. Given the complexity of the condition of obesity and the multivariate etiopathology of male subfertility/ infertility, this review is aimed to provide an updated concept on how obesity mediated hormonal modulation may affect male fertility parameters.
Authors and Affiliations
Sulagna Dutta, Anupam Biswas, Pallav Sengupta
Keywords
Related Articles
- EP ID EP648655
- DOI 10.4103/2305-0500.268133
- Views 155
- Downloads 0
Evaluation of infertile women: Mini-review
Evaluation of infertility indicated for women failed to conceive after one year of unprotected intercourse and for women over 35 years failed to conceive after 6 mo of unprotected intercourse, because the fertility decli...
Monozygotic twinning after donor egg intracytoplasmic sperm injection-A case report
We are reporting a case of monozygotic twinning after donor egg intracytoplasmic sperm injection (ICSI). A 34-year-old lady presented to our centre with primary infertility due to severe endometriosis and low egg reserve...
Effect of Diospyros kaki enriched extender on cattle bull sperm parameters and conception rate
Objective: To explore the effect of Diospyros kaki on cattle spermatozoa during chilling and cryopreservation. Methods: Five milliliter of blended Persimmon (Diospyros kaki) flesh was added to 45 mL TCF to obtain 10% sto...
Maternal reproductive health: Expression patterns of antioxidant enzyme selenoproteins of post-implantation embryos conceived by ethanol-treated murine mothers supplemented with 毩-tocopherol
Objective: To investigate if the protective effect of毩-tocopherol against the impact of ethanol on brain morphogenesis involved the activity of the selenoproteins phospholipid hydroperoxide glutathione peroxidase (PHGPx...
Melatonin as an antioxidant preserving sperm from domestic animals
The role of melatonin on sperm function as well as its use as antioxidant for sperm conservation is analysed in this review. Melatonin has been included in the cooling/freezing media for the conservation of spermatozoa....