OFF-LABEL USE OF ANTIBACTERIALS IN A CONTEXT OF ANTIMICROBIAL RESISTANCE THREAT
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 6
Abstract
Objective: The objective of the study was to describe the off-label use of antibacterial in prescriptions for hospitalized adult patients as per the Brazilian drug regulatory agency, namely, the National Health Surveillance Agency (ANVISA). Methods: This is a cross-sectional study with prescriptions for inpatients in a teaching hospital. Data collection and analysis were based on the checklist of the Medicine Prescription, Use and Administration Protocol of the Ministry of Health, where the off-label use is classified as per information of ANVISA’s Electronic Bulletin. Descriptive analyses were performed, and the method of logistic regression was used to evaluate the association between the off-label use of antibacterial and the explanatory variables age, gender, hospitalization clinic, and medical specialty. Results: About one-third of the antibacterial was prescribed for off-label use, and the frequency of administration was the primary use outside standards established in the products’ licenses (87.3%), and dose (7.4%) and the administration route was next. The third-generation cephalosporin was the most consumed class in this regimen (69.5%). In some cases, the off-label use was not supported by scientific evidence. The off-label use was positively associated with the variables gender (odds ratio [OR] = 2.48; confidence interval [CI] = 1.23–4.92) and the prescribing clinic (OR = 4.94; CI = 2.61–8.96). Conclusion: Off-label use is a frequent practice in the studied environment, and in the face of a dramatic scenario of increased antibacterial resistance, it is imperative to adopt measures for the standardization of records and the rational use of this class of drugs.
Authors and Affiliations
GISELE S LEMOS , IONARA VR MOTA , MARIO B ROSA , EDSON PERINI , CRISTIANE AM PÁDUA
Keywords
Related Articles
- EP ID EP608953
- DOI -
- Views 113
- Downloads 0
FORMULATION, IN VITRO AND EX VIVO CHARACTERIZATION OF MUCOADHESIVE BUCCAL TABLETS FOR ANTIHYPERTENSIVE DRUG
Objective: Olmesartan belongs to a class of angiotensin II receptor blockers. It is used in the treatment of hypertension. However, it undergoes extensive hepatic first-pass metabolism, resulting in low oral bioavailabil...
SALIVARY PROTEIN AND GLUCOSE LEVELS IN DIABETIC AND NON-DIABETIC PATIENTS - A REVIEW
Saliva is the most important tool to monitor various biochemical parameters including protein and glucose. Hence, it can be used as a tool to find if a patient is diabetic or nondiabetic. This review presents information...
STUDIES ON ANTICONVULSANT ACTIVITY OF ANNACYCLUS PYRETHRUM IN ALBINO MICE
ABSTRACTObjective: A study which involves in detecting anticonvulsant activity from Anacyclus pyrethrum roots by using maximal electroshock seizure (MES)in a dose-dependent way with the production of ethanolic extraction...
ACTIVE PHENOLIC CONSTITUENTS AND BRINE SHRIMP LETHALITY ASSAY OF HYDROALCOHOLIC EXTRACT OF Plectranthus amboinicus
Objective: Plectranthus amboinicus, (PA) leaves contain pharmaceutically important phyto constituents that attribute to greater medicinal values. The purpose of the present study was to investigate the active principles...
BIOACTIVITIES AND CHEMOPROFILING COMPARISONS OF CHENOPODIUM AMBROSIOIDES L. AND CHENOPODIUM BOTRYS L. GROWING IN KASHMIR, INDIA
Objectives: The objectives of the study were the gas chromatography-mass spectrometry (GC-MS) identification and comparison of the chemical constituents, evaluation of the antifungal and anticancer activities of two spec...