Oncogenic Human Papilloma Virus type/s Detection in Cytologically Abnormal Females – Clinical Relevance for Disease Management
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 8
Abstract
A precise subset of Human Papillomavirus (HPV) genotypes, called high-risk genotypes, has now been undeniably established as the cause of invasive cervical cancer. HPV16 and 18 account for 70% to 80% of cervical cancers. Present study was planned to detect and type the High risk HPV in cytologically abnormal women. 80 cervical brushings were collected and subjected for pap smear followed by Polymerase chain reaction and genotyping. 24(30%) cases came positive for high risk human papillomavirus. Pap abnormal cases, categorized as ASCUS, LSIL & HSIL were studied for presence of HR-HPV genotypes. 06, 27, 25, & 22 specimens were respectively in ASCUS, LSIL, HSIL & other cervical abnormalities categories out of which 01(0.16%), 07(25.9%), 12(48.0%), and 04(18.1%) were HR-HPV positive. Genotyping of HPV revealed that HPV type 16 with 10(41.6%) cases was the most prevalent type detected followed by HPV type 18 with 06(25.0%) cases and 03(12.5%), 03(12.5%) and 02(8.3%) cases respectively of HPV 16 and 18, HPV 31 and other HR-HPVs. Mixed infection of HPV type 16 and HPV type 18 was seen in 03 cases. HPV prevalence Genotypic characterization with respect to cytological status of the cervix is of clinical relevance for proper guidance screening and subsequent follow up of the patiets as well as provide the ideas for strategic evaluation to vaccine production & research to design the related therapeutics. Keywords: High risk Human Papilloma Viruses, Pap Smears, Cervical cancer, Polymerase Chain Reaction, Neoplasia
Authors and Affiliations
Narotam Sharma, Vishal Kumar, Gyanendra Awasthi, Ujjwal Srivastava, Rakhi Kaushik, Abhilasha Pant, Nadia Razdan
Keywords
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