One-Pot Synthesis of Novel Substituted Phenyl-1,5-dihydro-2Hbenzo[ 4,5]thiazolo[3,2-a]pyrimido[4,5-d]pyrimidine Derivatives as Potent Antimicrobial Agents
Journal Title: UNKNOWN - Year 2019, Vol 8, Issue 1
Abstract
In this paper, we have reported the synthesis of novel substituted phenyl-1,5-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimido[4,5-d]pyrimidine derivatives (4a-m). The title compounds were synthesized by the reaction of substituted 2-aminobenzothiazole, barbituric/thiobarbituric acid and substituted benzaldehydes using 2-3 drops of HCl in ethanol. The synthesized compounds were evaluated for their antimicrobial efficiency against various microbial strains at different concentrations. Among the tested compounds, the compounds 4k and 4j were found to be more active against all the tested pathogens. Additionally, selected compounds were screened for in silicomolecular docking studies.
Authors and Affiliations
Talavara Venkatesh, Yadav D Bodke, Nagaraj K, Ravi Kumar S
Keywords
Related Articles
- EP ID EP672246
- DOI -
- Views 63
- Downloads 0
Biological Scope of β-amino Acids and its Derivatives in Medical Fields and Biochemistry: A Review
Beta amino acids are the important macromolecules on earth and building blocks. They play key role in biological systems of living organisms. They are utilized as a part of arrangement for the most part pharmaceuticals....
Synthesis Characterization of New Polynucleating Ligands and their Biological Studies
This article summarizes synthesis of three new poly-nucleating ligands successfully in alcoholic medium. The ligands synthesized are characterized quantitatively and qualitatively by using NMR, IR...
Synthesis and Biological Evaluation of Novel 1,4-Disubstituted 1,2,3-Triazoles and Bis 1,2,3-Triazoles as Anti-Bacterial Agents
A library of novel 1,4-disbustituted 1,2,3-triazoles 3a-3k was prepared by using Click-chemistry concept. In this 1,3-dipolar cycloaddition, the 3-methoxy-4-(prop-2-yn-1-yloxy)benzaldehyde (1) was used as alkyne partner...
Synthesis of N-Substituted Benzamide Derivatives and their Evaluation as Antitumor Agents
A series of N-substituted benzamide derivatives designed based on Entinostat (MS-275) were synthesized, and characterized by IR, MS, 1H NMR and 13C NMR. Their anti-proliferative activity in vitro against four cell lines...
Synthesis and Antibacterial Activity of Novel Benzimidazole Linked 1,3,4-Oxadiazole Derivatives
With an intention to develop potent antimicrobial agents from the source of benzimidazole- 1,3,4-oxadiazole combined heterocyclic derivatives, novel 6-Chloro-2-(2-(5-(substituted phenyl)-1,3,4-oxadiazol-2-yl)ethyl)- 1H-b...