Oral premedication in children: A randomized study of a combination of oral midazolam, ketamine with atropine vs midazolam and atropine vs ketamine and atropine
Journal Title: Indian Journal of Clinical Anaesthesia - Year 2018, Vol 5, Issue 2
Abstract
Introduction Premedication is widely used in pediatric anesthesia in order to provide sedation and anxiolysis Aim of the study was to compare the effectiveness of combination of low dose oral midazolam and ketamine with oral midazolam or oral ketamine as premedicationMaterials and Methods 150 childrens between ages 2 and 10 were divided into 3 groups of 50 members each They received either combination of oral midazolam 05 mgkg and oral ketamine 3mgkg or oral midazolam 05 mgkg or oral ketamine 6 mg kg as pre medication Premedication was given 30 minutes before the induction of anesthesia Patients also received oral atropine 002mgkg along with the study drug Sedation and anxiolysis were assessed before giving premedication and at an interval of 10 minutes 20 minutes and 30 minutes after premedication Behavior at separation from parents and acceptance or response to venipuncture was also assessed at the end of 30 minutes Statistical analysis was performed using SSPE computer software version 16 Groups are compared using chi square testsResult We found that oral combination of midazolam 05 mgkg and ketamine 3 mgkg with atropine 002mgkg offered better sedation 96 children anxiolysis 76 children acceptance of parentral separation 80 children and comfortable venous cannulation 84 children We conclude that Combination of oral ketamine midazolam and atropine is a superior premedicating agent than using these drugs individuallyKeywords Ketamine Midazolam Premedication Pediatric
Authors and Affiliations
Ranjan Ramakrishna, Hemanth KJ, Sunil BV, Neeta S, Sonal Bhat
Keywords
Related Articles
- EP ID EP476470
- DOI 10.18231/2394-4994.2018.0048
- Views 80
- Downloads 0
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