ORAL SUPPLEMENTATION WITH PROBIOTICS IN PREVENTION OF NECROTIZING ENTEROCOLITIS IN PRETERM INFANTS WITH LOW BIRTH WEIGHT-A DOUBLE BLIND RANDOMIZED CONTROLLED STUDY
Journal Title: PARIPEX-Indian Journal of Research - Year 2017, Vol 6, Issue 7
Abstract
Background & Objectives Necrotizing enterocolitis (NEC) is a devastating gastrointestinal (GI) disease that predominantly affects, preterm low birth weight (LBW) infants and its associated with high morbidity and mortality. Current evidence suggest that probiotics are effective in decreasing NEC in preterm infants. In this study the primary objective was to study the role of oral probiotic supplementation to preterm infants in reducing incidence and severity of NEC. Methods Preterm infants <2 Kgs were studied and randomly assigned to case and control group. The case group received the supplements of probiotics mixed with their feeds and the control group received only plain feeds without probiotics. The probiotic used was Lacfid sachets (1g containing 109 spores of Saccharomyces boulardi , Lactobacillus rhamanosus, Lactobacillus acidophilus, Lactobacillus sporogenes, Bifidobacterium bifidum, Bifidobacterium longum).The primary outcome was incidence and severity of NEC. Results The case and control groups did not differ significantly in the confounding factors and demographic and clinical variables. The incidence of NEC was 1.89% in test group and 6.38% in control group (p<0.05).2% babies developed stage 1 NEC,3% babies developed stage 2 and 1% babies developed stage 3 disease. The incidence of sepsis in case group was 6.60% and 15.96% in control group (p<0.05).
Authors and Affiliations
Annie Romell, Piyush Jain
Keywords
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