Organ-specific autoimmunity in type 1 diabetes mellitus: Screening with respect to glycemic control
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 1
Abstract
Type 1 diabetes (T1D) is a tissue-specific autoimmune disease and often associated with other autoimmune diseases; so our study aimed to define the occurrence of thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) in autoimmune thyroid disease (AIT), tissue transglutaminase antibody (TTGAb) in celiac disease, And to evaluate the relationship between the presence of these antibodies and glycemic control. Our retrospective study included 60 Kuwaiti patients with T1D who attended and follow in Diabetes outpatient clinics of Kuwait primary health care centers during the period of 2014-2015. For them, recorded data for age, sex, duration of diabetes, Body Mass Index (BMI), HbA1c was reviewed. Patients were screened for the presence of Specific antibodies to islet antigens (ICAb), glutamic acid decarboxylase autoantibodies (GADAb), insulin autoantibodies (IAA), TPOAb, TGAb, TTGAb and also thyroid stimulating hormone (TSH) were measured by ELISA. Of the total 60 patients (20 men, 40women, mean age was17.95 ± (5.44) y; the mean duration of diabetes was 6.63 ± (4.27) y; mean HbA1c was 10.41± (1.96) %. Only 58 (96.7%) were positive for GADAb, 32 (53.3%) were positive for ICAb, and 48 (80%) were positive for IAA, 14 (23.3%) patients were positive for TPOAb, 11 (18.3%) were positive for TGAb, 10 (16.7 %) were positive for both TPOAb and TGAb; furthermore 8 (13.3%) patients were positive for TTGAb. Neither organ-specific autoimmune disease (AIT and celiac disease) nor pancreatic β cells autoantibodies had a significant association with the glycemic control. In our study, we confirmed the high prevalence of a second organ-specific autoimmune disease in individuals with type 1 diabetes. Also Subclinical forms of these disorders have no influence on diabetes control. Further research will be necessary to test these relationships in a prospective follow-up study.
Authors and Affiliations
Mohamed Ghada A. | Department of Internal Medicine, Assiut Faculty of Medicine, Assiut University, Egypt, Elsayed Amira M. | Department of Internal Medicine, Benha Faculty of Medicine, Benha University, Egypt, Corresponding author email: amiramohamady@gmail.com
Keywords
Related Articles
- EP ID EP11535
- DOI -
- Views 249
- Downloads 7
Sub-neurolytic dose of phenol for popliteal-sciatic nerve block under ultrasound guidance for the relief of ischemic leg pain
Ischemic leg pain is often intractable. Pain relief with conventional analgesics, opioids and non-opioids is often unsatisfactory. It provides only a sub-optimal pain relief in spite of the grievous side effects it caus...
OVARIAN ECTOPIC PREGNANCY- A CASE REPORT
Ectopic pregnancy (implantation anywhere outside the normal uterine cavity) is the most common pregnancy complication leading to mortality. In the era of artificial reproductive techniques and liberated life style, ecto...
The Effect of 8 weeks of combined training on the angle of lumbar lordosis and pain of women suffering from sciatica pain
Chronic low back pain is among the most commonly pains caused by malfunctions, poor physical condition, and mental stresses. Various non-surgical methods are recommended to reduce pain, to maintain mobility, and to min...
Labor induction and the risk of cesarean delivery among term pregnancies
Labor induction is one of the most common obstetric interventions. The aim of this study was to determine the relationship between induction and risk of cesarean section delivery for women with term pregnancies who were...
Toxoplasma gondii and Downregulation of Gamma Interferon
This study was designed to evaluate the gene expression level of IFN-γ in murine leukocytes treated by Toxoplasma gondii products in vivo using quantitative real time-PCR (Q-PCR) method. The mice considered as test gro...