Outcome of Pregnancy Complicated by Obstetric Cholestasis: A Prospective Study
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 3
Abstract
Introduction: Obstetric cholestasis (OC), also known as intrahepatic cholestasis of pregnancy (ICP), is a hepatic disease unique to pregnancy which presents with intense generalized pruritus without any skin rash. Objective: The aim is to study the outcome of pregnancy both maternal and fetal complicated by OC. Materials and Methods: A prospective, longitudinal, observational study was carried out in 75 patients with OC of pregnancy from January 2016 to December 2016 in LD Hospital, Government Medical College, Srinagar. Pregnant patients presenting with pruritus and with deranged liver function tests were taken for the study. Statistical analysis was performed. Results: A total of 75 patients diagnosed with ICP were studied. Maximum patients were primigravida and in age group of 21-25 years. Pruritus was noted more in winter season. Jaundice was seen in 29.34% of patients. Nearly 50.67% of patients had spontaneous onset of labor. Induction of labor was done in 38.67% of patients. A maximum number of patients, i.e., 57.33% had vaginal delivery. Lower segment cesarean section was done in 38.67%. A total of 12 patients had postpartum hemorrhage. Two patients had intrauterine fetal death (IUD) and one patient had still birth. About 9.33% of the neonates had low birth weight and A/S was favorable in majority of neonates and 16% of newborn babies required admission in neonatal intensive care unit because of meconium aspiration. Conclusion: We demonstrate increased risks of adverse maternal and perinatal outcomes, including stillbirth and IUD in OC. Our findings support the case for close antenatal monitoring of pregnancies affected by severe OC.
Authors and Affiliations
Neha Mahajan, Asima Afzal, Mohd Iqbal Lone
Keywords
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