Outcome of surfactant therapy in neonates with respiratory distress

Journal Title: Medpulse International Journal of Pediatrics - Year 2019, Vol 10, Issue 3

Abstract

Background:Respiratory Distress is the most common presenting complaints and remains a leading cause of neonatal morbidity and mortality worldwide. Objectives:This study was conducted to evaluate the effect andtheoutcome of exogenous surfactant therapy in neonates with respiratory distress due to RDS, Meconium aspiration syndrome and pneumonia. Materials and Methods:This prospective study was conducted in the SCABU andIntensive Care Unit (ICU) of Dhaka Shishu (Children) Hospital. Neonates presented with respiratory distress due to RDS, Meconium aspiration syndrome, PPHN and pneumonia were included in this study.All included neonates were treated with bovine origin semi-synthetic surfactant as rescue therapy. Surfactant was administered by using the standard procedure.Effects of surfactant therapy, type and duration of respiratory support, complications and outcome were assessed.Paired t-test was used to compare the effectiveness of surfactant use. Pvalue of <0.05 was considered significant.Results:Among the enrolled neonates about two-thirds (58.3%) were VLBW (<1500gm). Respiratory distress due to RDS was in 50.0% cases. All enrolled neonates were out-born and reached hospital within 8.4±2.1 hours of birth. Age of surfactant instillation was 19.5±6.8 hours and 91.7% neonates received surfactant within 24 hours of age.There was a significant (p<0.05) change in respiratory rate, SpO2, PCO2 and PO2 after six hours of surfactant administration. Respiratory support after surfactant administration required for a mean of 3.7±1.7 days and about half of them (41.6%) were managed by only nasal CPAP. Out of 12 neonates who received surfactant 25.0% developed complications and mortality rate was 25.0%.Conclusions:This study concluded that neonates with respiratory distress due to various causes improved with exogenous surfactant therapy.

Authors and Affiliations

Mahfuza Shirin, M Monir Hossain, Mohammad Abdullah Al Mamun

Keywords

Related Articles

Association of iron deficiency anaemia with febrile seizure in children

Background: Previous studies reported that iron deficiency could be a risk factor for Febrile Convulsion (FS) because both conditions are common in children of the same age. However, few studies described iron deficiency...

Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyper responsiveness and clinical asthma in nonsteroiddependent asthma in children

Several short-term studies have shown that inhaled steroids can reduce airway hyper responsive in asthma. To evaluate whether prolonged treatment can bring about full recovery, this double blind, randomized, control tria...

Study of congenital malformations and related maternal and foetal factors: Hospital based study

Background: Congenital malformation represents defects in morphogenesis during early fetal life. According to the World Health Organization (WHO) document of 1972. Aims and Objectives: To Study of Congenital Malformation...

Correlation of serum bilirubin level by transcutaneous blood and conventional blood sample

Background:Neonatal hyperbilirubinemia is a known, treatable risk factor for bilirubin encephalopathy, and is detectable by several methods. Universal pre-discharge newborn screening for hyperbilirubinemia has been propo...

Assessment of glycemic control, glucose variability, and hypoglycemic incidence using insulin degludec in children and adolescent with type I diabetes

Objective: The objective of this study is to study the most recent evidence on glucose variability using insulin degludec comparing it with insulin Glargine in children and adolescents with C-Pepde negative type I Diabet...

Download PDF file
  • EP ID EP615833
  • DOI -
  • Views 172
  • Downloads 0

How To Cite

Mahfuza Shirin, M Monir Hossain, Mohammad Abdullah Al Mamun (2019). Outcome of surfactant therapy in neonates with respiratory distress. Medpulse International Journal of Pediatrics, 10(3), 96-101. https://europub.co.uk/articles/-A-615833