Oxidant/Antioxidant Status in Patients with Behçet Disease
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2010, Vol 2, Issue 1
Abstract
Background. Increased oxidant stress and decreased antioxidant enzyme activities may result in tissue injury in Behçet’s disease (BD) patients. Aim. The aim of the study was to assess various selected markers of oxidative stress in patients with BD. Material and Methods. Thirty-two patients with BD and twenty-five healthy age- and sex- matched controls were recruited from the Rheumatology Department of Cairo University Hospital. Behçet’s Disease current activity form (BDCAF) was used in order to assess the disease activity. The following parameters were assayed: serum nitric oxide level (NO), serum malondialdehyde (MDA), serum hydrogen peroxide (H2O2), serum total antioxidant capacity (TAC). Reuslts. The present result showed that serum NO and TAC levels were significantly lower in BD patients, than in healthy controls (P<0.0001). Serum MDA and H2O2 were significantly higher in BD patients than in healthy controls (P<0.003 and P<0.001 respectively). Conclusion. Our results confirm the presence of oxidative stress in patients with Behçet’s Disease and suggest that the severity of Behçet’s Disease may arise from impaired antioxidant mechanisms.
Authors and Affiliations
Maather Mahgoub| Faculty of Medicine, Cairo University, Rheumatology and Rehabilitation Department, Cairo, Egypt, Hala Raslan| National Research Centre, Internal Medicine Department, Giza, Egypt, Heba Assal| National Research Centre, Internal Medicine Department, Giza, Egypt, Tamer Gheita| Faculty of Medicine, Cairo University, Rheumatology and Rehabilitation Department, Cairo, Egypt, Iman Fikry| National Research Centre, Internal Medicine Department, Giza, Egypt, Mehrevan Abd El-Moniem| National Research Centre, Medical Biochemistry Department, Giza, Egypt, Anwa| National Research Centre, Medical Biochemistry Department, Giza, Egypt
Keywords
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- EP ID EP8726
- DOI 10.3889/MJMS.1857-5773.2010.0087
- Views 341
- Downloads 20
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