Oxidative stress markers in patients of psoriasis with metabolic syndrome
Journal Title: IP Indian Journal of Clinical and Experimental Dermatology - Year 2018, Vol 4, Issue 3
Abstract
Introduction Psoriasis is a chronic inflammatory T cell mediated immune disorder characterized by the formation of erythematous scaly papules and plaquesObjective To do a comparative evaluation of the markers of oxidative stress namely glutathione peroxidase GP malondialdehyde MDA and superoxide dismutase SOD in patients of psoriasis with metabolic syndrome MS patients of psoriasis without metabolic syndrome and normal healthy subjectsMaterials and Methods 150 subjects in the age group of 1870 years were included in the study Group A consisted of 50 psoriasis patients with metabolic syndrome Group B consisted of 50 psoriasis patients without metabolic syndrome while Group C had 50 normal healthy individuals Thorough history was taken and clinical examination was done The punch biopsy was performed for confirmation of the diagnosis of psoriasis Serum markers of oxidative stress were measured in each case and these values were then statistically compared among all the groupsResults On comparison of the groups the mean values of Superoxide dismutase and Glutathione peroxidase were least in Group A 2483 Uml 6105 Uml followed by Group B 280 Uml 68683 Uml and were maximum in Group C 395 Uml 140583 Uml whereas the mean value of Malondialdehyde was maximum in Group A 10 nmolml followed by Group B 07 nmolml and Group C 013 nmolml On comparing these values among different groups all the values were highly significant pConclusions Free radical mediated oxidative stress play an important role in the pathogenesis of psoriasis especially when it is associated with metabolic syndrome Therefore antioxidants can have a preventive as well as a therapeutic role in such patientsKeywords Glutathione peroxidase GP Malondialdehyde MDA Metabolic syndrome MS Oxidative stress OS Psoriasis superoxide dismutase SOD
Authors and Affiliations
Saurabh Sharma, Roopam Bassi, Manpreet Kaur
Keywords
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- EP ID EP488886
- DOI 10.18231/2581-4729.2018.0038
- Views 86
- Downloads 0
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