p73 Expression in Odontogenic Lesions - An Immunohistochemical Study
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 10
Abstract
Introduction: p73 may have a role in oncogenesis of odontogenic lesions.The aim of the study was to carry out the immunohistochemical study of p73 in a total of 80 cases of dentigerous cyst, Keratocystic odontogenic tumor (KCOT), Unicystic Ameloblastoma and Ameloblastoma. Material and methods: Immunohistochemical method was carried out using p73 antibody. The percentage of immunopositive cells was calculated in the cyst lined by epithelium and ameloblastoma islands. Result: p73 expression was marked in all types of odontogenic lesions.The innumopositivity of p73 was marked throughout the lining epithelium of KCOT except parakeratinized surface layer. In dentigerous cysts, very few basal and suprabasal cells expressed immunopositivity. Peripheral cells of ameloblastoma showed p73 expression. Immunopositivity of of p73 expression in lesions of odontogenic origin suggests that p73 is important in differentiation and proliferation of odontogenic epithelial cells. Conclusion: p73 protein represents a basal cell marker, and it is not expressed in mature differentiated cells. Clinical significance is to establish p73 as an independent prognostic biomarker in Odontogenic lesions.
Authors and Affiliations
Preethi Sharma, Madhuri Gawande, Minal Chaudhary, Prajakta Zade, Rajul Ranka, Swati Pattil
Keywords
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