PARAMETERS AND MORPHOLOGICAL CHANGES OF ERYTHROCYTES IN COVID-19 SUBJECTS
Journal Title: International scientific journal Science and Innovation - Year 2023, Vol 2, Issue 8
Abstract
Objective: to assess the morphological abnormalities of red blood cells (RBC) in patients with COVID-19 and cardiovascular system (CVS) pathology. Material and methods. The study included 142 patients who were divided into 3 groups according to the following principle: combination of COVID-19 and CVS pathology (group 1, n=56); COVID-19 without CVS pathology (group 2, n=44); patients with CVS pathology without COVID-19 (group 3, n=42). Peripheral blood erythrocytes were studied. Morphological studies were carried out in the laboratories of pathological anatomy of the State Institution âRSSPMC for surgery named after V.Vakhidov" and RSH Zangiota-1. Results. Morphological features of peripheral blood erythrocytes in COVID-19-associated cardiovascular syndrome were revealed, characterized by an increase in the frequency of elevated erythrocyte distribution width (RDW) from 45.5% to 67.9% (p<0.05), and the average RDW from 13.1% (11, 8-15.4%) to 14.3% (12.6-15.8%) (p<0.0001); an increase in the proportion of abnormal forms from 13.6% in the isolated course of COVID-19 to 32.1% in the combination of COVID-19 with cardiovascular pathology (p<0.05), mainly due to ridged erythrocytes from 6.4+0.5% to 8.2+0.6% (p<0.001) and the proportion of irreversible forms of erythrocytes from 1.6+0.1% to 3.1+0.3% (p<0.001) increasing the risk of transferring the patient to the ICU (RR=6.0) and death (RR=4.33). Patients with more than 20% RBC abnormality had a statistically significant higher ICU admission rate (50.0%, 9 of 18; RR=6.0) than patients with less than 10% RBC abnormality (8.33%, 1 of 12, p=0.049), and patients with 10-20% abnormal RBCs (7.7%, 2 of 26, p=0.005). Conclusion. Patients with COVID-19-associated cardiovascular syndrome have a significant morphological heterogeneity in the shape and size of erythrocytes and their relationship with the progression and outcome of the disease.
Authors and Affiliations
Ibadov Raufbek Ravshanovich, Akilov Khabibulla Ataullayevich, Mardonov Jamshid Normurotovich
Keywords
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- EP ID EP721104
- DOI 10.5281/zenodo.8219267
- Views 54
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