PARAMETERS AND MORPHOLOGICAL CHANGES OF ERYTHROCYTES IN COVID-19 SUBJECTS
Journal Title: International scientific journal Science and Innovation - Year 2023, Vol 2, Issue 8
Abstract
Objective: to assess the morphological abnormalities of red blood cells (RBC) in patients with COVID-19 and cardiovascular system (CVS) pathology. Material and methods. The study included 142 patients who were divided into 3 groups according to the following principle: combination of COVID-19 and CVS pathology (group 1, n=56); COVID-19 without CVS pathology (group 2, n=44); patients with CVS pathology without COVID-19 (group 3, n=42). Peripheral blood erythrocytes were studied. Morphological studies were carried out in the laboratories of pathological anatomy of the State Institution “RSSPMC for surgery named after V.Vakhidov" and RSH Zangiota-1. Results. Morphological features of peripheral blood erythrocytes in COVID-19-associated cardiovascular syndrome were revealed, characterized by an increase in the frequency of elevated erythrocyte distribution width (RDW) from 45.5% to 67.9% (p<0.05), and the average RDW from 13.1% (11, 8-15.4%) to 14.3% (12.6-15.8%) (p<0.0001); an increase in the proportion of abnormal forms from 13.6% in the isolated course of COVID-19 to 32.1% in the combination of COVID-19 with cardiovascular pathology (p<0.05), mainly due to ridged erythrocytes from 6.4+0.5% to 8.2+0.6% (p<0.001) and the proportion of irreversible forms of erythrocytes from 1.6+0.1% to 3.1+0.3% (p<0.001) increasing the risk of transferring the patient to the ICU (RR=6.0) and death (RR=4.33). Patients with more than 20% RBC abnormality had a statistically significant higher ICU admission rate (50.0%, 9 of 18; RR=6.0) than patients with less than 10% RBC abnormality (8.33%, 1 of 12, p=0.049), and patients with 10-20% abnormal RBCs (7.7%, 2 of 26, p=0.005). Conclusion. Patients with COVID-19-associated cardiovascular syndrome have a significant morphological heterogeneity in the shape and size of erythrocytes and their relationship with the progression and outcome of the disease.
Authors and Affiliations
Ibadov Raufbek Ravshanovich, Akilov Khabibulla Ataullayevich, Mardonov Jamshid Normurotovich
Keywords
Related Articles
- EP ID EP721104
- DOI 10.5281/zenodo.8219267
- Views 48
- Downloads 0
SCIENTIFIC-THEORETICAL FOUNDATIONS FOR THE DEVELOPMENT OF CREATIVE INTELLECTUAL COMPETENCIES OF FUTURE PHYSICS TEACHERS
This article explores the scientific-theoretical foundations essential for developing creative intellectual competencies in future physics teachers. It delves into constructivism, cognitive development theories, integrat...
TASK-BASED LANGUAGE LEARNING
Task-based learning is an approach to language learning where learners are given interactive tasks to complete. In order to do this, they need to communicate. Once the task is complete, then the teacher discusses the lan...
DOMBRA, KOBYZ, SYBYZGY – OUR HERITAGE IS AS RICH AS THE SEA
In this article, it is said that the Kazakhs are the heirs of the wonderful culture of the nomads of the Great Steppe for thousands of years, and they continue to carry the foundations of this great culture to this day....
TRANSFORMING ENGINEERING EDUCATION WITH COMPUTER GRAPHICS: A NEW PEDAGOGICAL APPROACH
The article explores an innovative approach to engineering education through the integration of computer graphics aimed at bridging the gap between traditional teaching methods and the evolving technological design of th...
ISSUES OF DEVELOPMENT OF SELF-CONSCIOUSNESS IN MOTHER LANGUAGE AND LITERATURE LESSONS
One of the global issues in the development of today's society shows the need to pay attention to the acquisition of new knowledge and skills, their constant updating and development. Intelligence among young learners is...