Patterns of Cutaneous Adverse Drug Reaction at a Tertiary Care Hospital, Central India, MP
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 12
Abstract
Aim of this prospective, hospital based study is to determine the pattern of cutaneous adverse drug reactions (ADRs) and their causative drugs. The study was conducted in the department of Pharmacology and department of Medicine, at SS Medical College and associated SGM Hospital, Rewa, MP between Oct 2014 to Sept 2015; a total 130 cases were enrolled with suspected ADRs after taking written informed consent. In this study maximum (25%) patients were belonged to 18-25 years of age group, of these 55% were males and 45% females. Mean (± SD) age of these patients was 34.84 ± 20.99 years. The skin and mucous membrane are most commonly (52.29%) affected organ system with the suspected ADRs followed by central nervous system (9.19%) and gastrointestinal system (8.62%). Among the cutaneous ADRs; maximum 51.64% were skin rashes followed by 29.67% pruritus, 5.49% oral ulcers, 3.29% Stevens-Johnson syndrome (SJS), 2.19% bullous eruption, 2.19% swelling lips, 2.19% TEN, 1.09% oral candidiasis, 1.09% red man syndrome and 1.09% hair changes. Of these ADRs; most were associated with use of antimicrobials (82.41%) followed by NSAIDs (14.28%). Amongst AMAs maximum 20.97% were associated with fluoroquinolones followed by 18.68% cephalosporin, 10.98% penicillin and 5.49% sulphonamide.In this study skin and mucous membrane are most commonly (52.29%) affected organ system; skin rashes and pruritus are the most common cutaneous ADRs and majority of cases were associated with use of antimicrobials include fluoroquinolones and cephalosporins. The major drawback of this study is it’s under reporting of ADRs; hence our study does not yield the exact incidence of suspected ADRs. Keywords:Cutaneous adverse drug reactions (CADR); Skin rashes; Toxic epidermal necrolysis (TEN); Stevens-Johnson syndrome (SJS).
Authors and Affiliations
Singh Prabhakar, Raj Bhupendra, Pandey Vivek, Indurkar Manoj, More Pankaj
Keywords
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