Peculiarities of the Spectrum of Chromosome Aberrations in the Peripheral Blood Lymphocytes in Cases of Brain Gliomas and their Correction with Verapamil and Ketamine
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 6
Abstract
Abstract: This work is devoted to question, is the genetic anomalies in glioma cellular genome is a subject to reasons or consequences of the malignant process? For answer on this question new approach was used, such as comparison of the genetic abnormalities data between brain gliomas and cerebral brain injury. This two pathologies have different view of inflammations, and it influence on the genome can investigate by cytogenetic methods. Making into account the connection between membrane and cell nuclear, pharmacology medications verapamil and ketamine was used for possible stabilization of nuclear chromosomes. Thus, a disorder of cellular genome in cases of inflammatory processes of neoplastic and non neoplastic genesis largely is defined with charge properties of cellular membranes and the influence of channel antagonists (verapamil and ketamine) on cellular membranes promotes the normalization of charge properties of membranes and stabilization of cellular genome. This result is evidence about such fact, that more of the genetic aberrations are not reasons, but only consequences of malignant process and it is very important result for utilization in gene therapy. Keywords: Brain gliomas, Genetic aberrations, Tumor-association inflammation, Cytogenetic methods, Membrane-nuclear interactions, Verapamil, Ketamine, and Stabilization of nuclear chromosomes.
Authors and Affiliations
Gridina N. Ya, Maslov V. P, Kotovsky V. Y, Draguntsova N. G
Keywords
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