Peel-off gel formulation from black mulberries (Morus nigra) extract as anti-acne mask
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2017, Vol 7, Issue 9
Abstract
Background: Acne is a skin disease characterized by chronic inflammation in the polisebasea that often occurs in adolescence. Utilization of the black mulberry fruit with a high phenolic is one alternative for the treatment of acne. Aims and Objectives: The aims of this research are to develop and test a peel-off mask gel prepared from black mulberries (Morus nigra) extracts, which has antibacterial activity against Staphylococcus epidermidis and Propionibacterium acnes. Materials and Methods: Black mulberry fruit was extracted with the maceration method by using ethanol (96%). Then, the antibacterial activity of the extract was determined by the disc-diffusion method, while the mean inhibitory concentration (MIC) and mean bactericidal concentration (MBC) were determined by the microdilution method. Then, the extract was formulated into the base of the peel-off mask gel containing variations in concentration of polyvinyl alcohol (7%, 9%, and 10%) and hydroxypropyl methylcellulose (2% and 2.5%). The formulations prepared were evaluated for their physical properties, including organoleptic behavior, homogeneity, pH, viscosity, spreadability, and drying time. Irritation tests were performed, and antibacterial activity of the formulation was also assessed. Results: The results showed that the black mulberry fruit extract has antibacterial activity with MIC value of 2.5% against S. epidermidis and P. acnes, while MBC values were 2.5% and 5%, respectively. Formulations with the best results of physical evaluation were obtained for the formula containing polyvinyl alcohol at 7% and hydroxypropyl methyl cellulose at 2.5%. The antibacterial activity of the peel-off mask gel formulation from black mulberries (M. nigra) extract occurs with 3 × MIC and produce inhibition zone 6.11 ± 3.2 mm against S. epidermidis and 5.43 ± 0.6 mm against P. acnes. Conclusion: It can be concluded that the peel-off mask gel prepared from black mulberry (M. nigra) fruit extract is effective as well as safe to be used as a topical preparation.
Authors and Affiliations
Arif Budiman, Diah Lia Aulifa, Arif Satria Wira Kusuma, Insan Sunan Kurniawan, Astri Sulastri
Keywords
Related Articles
- EP ID EP291953
- DOI 10.5455/njppp.2017.7.0413123052017
- Views 96
- Downloads 0
Development of gel composition and technology based on pyrimidine substance
Background: This work was conducted in the framework of quality by design project involving the production of a pharmaceutical gel. Preliminary work included the identification of the quality target product profiles from...
Chronomorphological and pressure changes in a sign of aging - pseudoexfoliation of the eye
Background: Pseudoexfoliation (PXE) is an age-related disorder, a risk factor for glaucoma. The aim of this research was to study the chronomorphological and pressure changes in PXE of the eye. Aims and Objectives: To de...
Association of plasma glucose, serum lipid profile, and liver enzymes with non-alcoholic fatty liver disease - A case–control study
Background: The prevalence and complications of nonalcoholic fatty liver disease (NAFLD) have increased dramatically over the past decade. The pandemic of lifestyle disorders and their role in the development of NAFLD en...
A study to analyze the prevalence of nervous anastomosis (Martin–Gruber) in medical students
Background: In nerve conduction laboratory, various types of case s are encountered. These are generally referred for electrophysiological investigation of the most common s yndromes such as carpel tunnel syndrome wh...
Effectiveness of aerobic exercise and balanced diet for motor and functional recovery of stroke survivors with and without diabetics and post stroke diabetics
Background: Diabetes is a strong risk factor for stroke, it is unsettled stroke is different in patients with and without diabetes. Hyperglycemia has been observed after an acute stroke and is associated with poor progno...