Pelletization as a key tool for oral drug delivery: A review
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 10
Abstract
Multiparticulate systems prove to be promising system for oral drug delivery. Pelletization is a process in which fine powders or granules are converted into free flowing semi-spherical units referred as pellets. Pellets are the multiple unit dosage forms which can be formulated in the form of suspensions, capsules or disintegrating tablets. This review outlines manufacturing and evaluation of spherical pellets. The manufacturing techniques include extrusion/spheronization, hotmelt extrusion, layering, globulation, compression, balling, freeze pelletization and cryopelletization. Evaluation of quality of the pellets is discussed with reference to the shape, size distribution, surface morphology, specific surface area, density, friability, tensile strength.
Authors and Affiliations
Af i fa Bathool*, Gowda D. Vi shakant e , Mohammed S. Khan, Vikas K Gupta
Keywords
Related Articles
- EP ID EP86633
- DOI -
- Views 155
- Downloads 0
Stability of Piroxicam As Its And With Selected Pharmaceutical Excipients
The thermal analysis (DTA,TGA) and mass spectrometry (Ms) have been used to study the stability of piroxicam in dry air flux.The kinetic energy was 107.06 KJ/mol and freqency factor 1.49 x 10 10 mim-1 .Reformulatio...
Antibacterial and Antifungal Activity of Colocasia esculenta Aqueous Extract: An Edible Plant
The in-vitro antimicrobial activity in aqueous extract of Colocasia esculenta (AECE) leaves were studied against gram positive bacterial strains i.e. Streptococcus mutans (MTCC-890), Bacillus subtillis (MTCC-121), gram n...
Emergence of ‘Super Bug’ and Use of Antibiotics: What We Learned, What We Have Yet to Learn?
Recent reports on emergence of a multidrug resistant ‘superbug’ have given the world a warning call against irrational use of antimicrobials. Few examples of most dangerous bugs include MRSA, Klebsiella Penumonia, vancom...
Cervical cancer : Promoter hypermethylation and its reversal
Cervical cancer is one of the most common cancer in women resulting in 0.4% of the total mortality across the world. A number of epigenetic alterations occur during all stages of cervical carcinogenesis including global...
Evaluation of the cell-free coelomic fluid of the earthworm Eudrilus euginiae to induce apoptosis in SiHa cell line
The cell-free coelomic fluid (CF) was collected from the earthworm Eudrilus euginiae and tested for toxicity at 20, 40, 60, 80 and 100 µl.ml -1 concentrations by MTT assay in SiHa cells invitro. Percentage of inhibit...