Pentazocine pretreatment suppresses fentanyl-induced cough.
Journal Title: Pharmacological Reports - Year 2010, Vol 62, Issue 4
Abstract
This study evaluated the effect of pentazocine pretreatment on fentanyl-induced cough. With ethics committee approval, 277 ASA I-II patients, aged between 19 and 63 years, undergoing various elective surgeries during general anesthesia, were enrolled in this prospective, randomized, double-blind, placebo-controlled clinical trial. All patients were randomly assigned to one of three groups. Group I (n = 92) and Group II (n = 93) received normal saline, while Group III (n = 92) received pentazocine 0.5 mg·kg(-1) 5 min prior to receiving fentanyl, Patients belonging to Groups II and III were administered 2 μg/kg fentanyl intravenously over 2 s after the first injection; Group I served as a negative control for fentanyl. Physiologic indicators such as heart rate (HR), non-invasive blood pressure (NBP) and pulse oximetry oxygen saturation (SpO(2)) of patients were recorded before giving pentazocine or normal saline 1 minute after fentanyl injections. The incidence of cough was recorded and graded as mild (1-2), moderate (3-5) and severe (> 5), depending on the number of coughs observed [13]. The incidence of cough was 0%, 22.6% and 4.3% in Group I, Group II and Group III, respectively. There was no significant difference in SpO(2) for the duration of the trial among the three groups. Premedication with intravenous pentazocine can minimize the incidence of fentanyl-induced cough and has no influence on blood pressure, heart rate, and SpO(2) compared with Group II.
Authors and Affiliations
Qing Ai, YiPing Hu, YanJuan Wang, ShuoXiong Wu, Zhong Qin, Jun Wang, GuiLong Wang, JianYu Zhang, MingHao An
Keywords
Related Articles
- EP ID EP139601
- DOI -
- Views 96
- Downloads 0
Effect of diazepam and chlorpromazine on proliferative activity and vascular endothelial growth factor (VEGF) secretion from cultured endothelial HECa10 cells in vitro.
Diazepam and chlorpromazine - psychotropic agents widely used for the amelioration of anxiety, depression, and psychosis, have been found to affect cell proliferation. We have checked whether these drugs influence prolif...
Down-regulation of thymic stromal lymphopoietin by curcumin.
Background: Thymic stromal lymphopoietin (TSLP) is a cytokine implicated in the pathogenesis of allergic diseases such as asthma, atopic dermatitis and allergic rhinitis. Curcumin has various effects such as antidepressa...
Effect of benzothiazole/piperazine derivatives on intracerebroventricular streptozotocin-induced cognitive deficits.
Background: In this study, benzothiazole-piperazine compounds were synthesized by condensing the functional groups of donepezil (DNP), FK-960, and sabeluzole, which are known to have therapeutic potential against Alzheim...
N-methylnicotinamide failed to induce endothelial prostacyclin release in perfused rat hindquarters.
N-methylnicotinamide, a nicotinamide derivative, possesses anti-thrombotic activity, although the mechanism of its action is unclear. Using a rat model of isolated perfused hindlimb, we tested whether this metabolite of...
Effect of interleukin 6 deficiency on the expression of Bcl-2 and Bax in the murine heart.
Interleukin 6 (IL-6) is a pleiotropic cytokine that is highly expressed in response to ischemia and reperfusion. It has dichotomous roles in the heart, functioning both as an inflammatory mediator as well as a protective...