Personalized 18FDG Dose Synthesis Using BG-75 Generator: 1st Year Experience at JCI Accredited Tertiary Care Hospital in Pakistan
Journal Title: Journal of Biomedical Physics and Engineering - Year 2019, Vol 9, Issue 4
Abstract
Background: Compact cyclotrons are getting popular to fulfill enormous current demands of PET tracers. Aga Khan University Hospital, Karachi, Pakistan has acquired the first smallest footprint of BG-75 Generator for 18FDG-based PET/CT clinical imaging. We are sharing our experience of BG-75 in the first year (December 2015-November 2016) after commissioning. Material and Methods: BG-75 Generator (ABT, USA) was installed in available space without major design modification. It has a self-shielded mini-cyclotron (7.5 MeV proton beam, positive ion with current < 5µA) to produce [18F]F-, an automated card-based radiochemistry module to produce 18FDG and automated QC module to perform tests upon each batch of 18FDG. Data were collected for yields of [18F]F-, 18FDG, QC and radiation safety parameters. Results: Total 545 runs in 167 days (3±01 runs/day) were made. Average yield with 60 minute bombardment using 4.5 µA current was 37 mCi and 21 mCi for [18F] F- and 18FDG, respectively. Total 29 runs had chemistry or QC failures and were discarded. Remaining 516 batches were used to perform imaging upon 1370 patients (8±03 patients/day). Radiation dose in BG-75 suite and effective doses to 02 operators were within statutory limits. Conclusion: BG-75 Generator provides safe, dependable and sustainable supply of 18F-Fluoride for 18FDG and other low-volume clinical PET imaging. Its compactness and automation need minimal space and manpower. Radiation dose rate in cyclotron suite and personal dosimetry were also found within safe limits. Its Doseon-Demand workflow offers a new concept of Personalized Dose Preparation which is currently not possible with a conventional cyclotron. Citation: Zaman M. U, Fatima N, Mehdi S. U, Sami M, Khan Kh, Khan G. Personalized 18FDG Dose Synthesis Using BG-75 Generator: 1st Year Experience at JCI Accredited Tertiary Care Hospital in Pakistan. J Biomed Phys Eng. 2019;9(4):409-416. https://doi.org/10.31661/jbpe.v0i0.792
Authors and Affiliations
M. U. Zaman, N. Fatima, S. U. Mehdi, M. Sami, Kh. Khan, G. Khan
Keywords
Related Articles
- EP ID EP647173
- DOI -
- Views 81
- Downloads 0
Evaluation of Blood Parameters Alteration Following Low-dose Radiation Induced by Myocardial Perfusion Imaging
Introduction: With increasing the usage of myocardial perfusion imaging (MPI) for the diagnosis of ischemic heart disease, we aimed to evaluate the side effects of low-dose radiation induced by this technique on blood el...
Craniospinal Irradiation in Medulloblastoma using High Energy Medical Linear Accelerator: an Innovative Approach to Planning Technique
Background: Craniospinal irradiation (CSI) of medulloblastoma poses technological challenges due to the involvement of large treatment volume. Commonly, the whole treatment length is covered with two different isocentric...
Optimization of Brain Tumor MR Image Classification Accuracy Using Optimal Threshold, PCA and Training ANFIS with Different Repetitions
Background: One of the leading causes of death is brain tumors. Accurate tumor classification leads to appropriate decision making and providing the most efficient treatment to the patients. This study aims to optimize b...
Enhancement of the Dose on 12 MV Linac with Free Flattening Filter Mode
Purpose: In the last years, some studies investigated dosimetric benefits of a free flattening filter for the photon mode in the radiotherapy field. This study aims to provide a theoretical study published and analysis o...
Correlation between Trunk-Pelvis InterSegmental Coordination Parameters during Walking and Disability Level in Chronic Low Back Pain Patients
Background: Chronic low back pain (CLBP) disability has been particularly frustrating because its treatment has been a great therapeutic challenge. Disability has been suggested to depend on different factors that should...