Closed- and Open-loop Deep Brain Stimulation: Methods, Challenges, Current and Future Aspects
Journal Title: Journal of Biomedical Physics and Engineering - Year 2018, Vol 8, Issue 2
Abstract
Deep brain stimulation (DBS) is known as the most effective technique in the treatment of neurodegenerative diseases, especially Parkinson disease (PD) and epilepsy. Relative healing and effective control of disease symptoms are the most significant reasons for the tangible tendency in use and development of this technology. Nevertheless, more cellular and molecular investigations are required to reveal the detailed mechanism of DBS. Here, we reviewed the methods, challenges and the ways to overcome the limitations of DBS. Also, challenges in probe fabrication technology, material selection, related mechanical stability and biocompatibility concerns are discussed. Finally, closed- and open-loop stimulation systems were compared.
Authors and Affiliations
P. Ghasemi, T. Sahraee, A. Mohammadi
Keywords
Related Articles
- EP ID EP453804
- DOI -
- Views 74
- Downloads 0
Thyroid Ultrasonography in Differentiation between Graves’ Disease and Hashimoto's Thyroiditis
Purpose: Graves' disease and Hashimoto's thyroiditis are the most common causes of hyper and hypothyroidism, respectively. Differentiation of these 2 diseases, if the patient is euthyroid, may sometimes be extremely diff...
Evaluation of Gold Nanoparticle Size Effect on Dose Enhancement Factor in Megavoltage Beam Radiotherapy Using MAGICA Polymer Gel Dosimeter
Background: Gold nanoparticles (GNPs) are among the most promising radiosensitive materials in radiotherapy. Studying the effective sensitizing factors such as nanoparticle size, concentration, surface features, radiatio...
Designing and Developing Automatic Trolley for Washing and Dressing the Wounds
Introduction: Many items are needed for dressing including sterile dressing set, antiseptic and washing solutions, leucoplast tape, waste bin for infectious garbage, waste bin for noninfectious garbage, safe disposal tra...
Reducing Radiation Doses in Female Breast and Lung during CT Examinations of Thorax: A new Technique in two Scanners
Background: Chest CT is a commonly used examination for the diagnosis of lung diseases, but a breast within the scanned field is nearly never the organ of interest. Objective: The purpose of this study is to compare the...
Diagnosis of OCD Patients Using Drawing Features of Bender Gestalt Shapes
Background: Since psychological tests such as questionnaire or drawing tests are almost qualitative, their results carry a degree of uncertainty and sometimes subjectivity. The deficiency of all drawing test is that the...