Pharmacokinetics and Tissue Residues of Levofloxacin in Normal and Aeromonas Hydrophilia Infected Catfish (Clarias Lazera)
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2014, Vol 4, Issue 10
Abstract
The pharmacokinetics of levofloxacin was studied following intravenous and oral (single & repeated) administrations. Following a single intravenous injection of 10 mg/kg.b.wt of levofloxacin in normal catfish (Clarias Lazera), serum concentration-time curve was best described by a two compartments open model with elimination half life (t0.5(β)= 11.43 h), volume of distribution (Vdss=172.47ml/kg) and total clearance of the drug (CLtot= 0.030 ml/kg/min). The mean systemic bioavailability following oral administration in normal catfish was 46.29 %. The extent of serum protein binding of levofloxacin in catfish was 15.8 %. Following oral administration of 10 mg/kgb.wt, the serum concentrations of levofloxacin following repeated oral administration of 10 mg /kg b.wt every 30 hours for four doses in normal and experimentally Aeromonas hydrophilia infected catfish (Clarias Lazera), peaked 8 hours after each oral dose with lower significant values recorded in experimentally infected catfish (Clarias Lazera) than in normal ones. Levofloxacin showed accumulative behavior in serum of catfish. Results of this study indicated that levofloxacin was useful for treatment of Aeromonas hydrophilia infections in catfish (Clarias Lazera). Levofloxacin was assayed in blood ,muscles with skin after 102 hours post last dose and after 150 hours post last dose in liver and kidney following administration of 10 mg/kg b.wt every 30 hours for four doses.
Authors and Affiliations
M. G. A. El-Sayed , A. A. A. El-Komy , F. I. El-Sayed
Keywords
Related Articles
- EP ID EP116397
- DOI -
- Views 119
- Downloads 0
Phosphorylated Connexin 43 Protein Levels Attenuation in the Retina of Adult Diabetic Male Rats, by Regular Moderate Exercise
Cell-to-cell interactions, through gap junctions that composed of connexin subunits, are now thought to be important in the molecular biology of diabetes. Raised phosphorylated connexin43 levels are considered an importa...
Massive Haemothorax and Tension Pneumothorax Due to Fractured Second Rib: Case Report
Massive haemothorax and tension pneumothorax due to injury of internal thoracic vein and second rib fracture after blunt trauma is very rare. Possible mechanisms of injury to the thoracic vein include fracture of an bony...
Combined Antimicrobial Effect Against Some Isolated Bacteria from Chickens
This study evaluates the activity of amoxicillin in combination with flumequine against some resistant strains. A total of 100 samples were collected from clinical diseases chickens in farms located in Sharkia governorat...
Cervical Cancer: An Emerging Public Health Issue in Bayelsa State Metropolis
The incidence of cervical cancer among women in Bayelsa State metropolis was studied. A total of four hundred and fifty (450) Pap smear were obtained from women age between 10 years and 70 years. An incidence of 1.5% was...
Resting Electrocardiogram of Top Athlete: Comparative Study between Football Players and Wrestlers in Senegal
Regular and intensive physical activity induces the "athlete's heart". So we compared the heart function of football players and wrestlers. We conducted a cross-sectional study from 01 April to 31 August 2014, involving...