Pharmacokinetics and Tissue Residues of Levofloxacin in Normal and Aeromonas Hydrophilia Infected Catfish (Clarias Lazera)
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2014, Vol 4, Issue 10
Abstract
The pharmacokinetics of levofloxacin was studied following intravenous and oral (single & repeated) administrations. Following a single intravenous injection of 10 mg/kg.b.wt of levofloxacin in normal catfish (Clarias Lazera), serum concentration-time curve was best described by a two compartments open model with elimination half life (t0.5(β)= 11.43 h), volume of distribution (Vdss=172.47ml/kg) and total clearance of the drug (CLtot= 0.030 ml/kg/min). The mean systemic bioavailability following oral administration in normal catfish was 46.29 %. The extent of serum protein binding of levofloxacin in catfish was 15.8 %. Following oral administration of 10 mg/kgb.wt, the serum concentrations of levofloxacin following repeated oral administration of 10 mg /kg b.wt every 30 hours for four doses in normal and experimentally Aeromonas hydrophilia infected catfish (Clarias Lazera), peaked 8 hours after each oral dose with lower significant values recorded in experimentally infected catfish (Clarias Lazera) than in normal ones. Levofloxacin showed accumulative behavior in serum of catfish. Results of this study indicated that levofloxacin was useful for treatment of Aeromonas hydrophilia infections in catfish (Clarias Lazera). Levofloxacin was assayed in blood ,muscles with skin after 102 hours post last dose and after 150 hours post last dose in liver and kidney following administration of 10 mg/kg b.wt every 30 hours for four doses.
Authors and Affiliations
M. G. A. El-Sayed , A. A. A. El-Komy , F. I. El-Sayed
Keywords
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