PHARMACOKINETICS, BIOAVILABILITY AND TISSUE RESIDUES OF AMIKACIN IN BROILER CHICKENS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 1
Abstract
The disposition kinetics and serum availability of amikacin in broiler chickens after single intravenous (IV) and intramuscular (IM) administrations of 10 mg/kg body weight were investigated. The concentrations of the drug in the serum were measured using microbiological assay on samples collected at frequent intervals after drug administration. Following intravenous injection, the serum concentration-time curves were best described by a two compartment open model. The elimination half-life (t1/2β), volume of distribution at steady state (Vdss) and total body clearance (Cltot) of amikacin were 4.48 h, 501.03 ml/kg and 0.08 L/h/kg, respectively. After intramuscular injection of amikacin at the same dose the peak serum concentrations (Cmax) were 15.25 μg/ml and were obtained at 1.89 h (tmax), the elimination half-life (t1/2el) were 5.23 h and absorbtion half-life (t1/2ab) were 0.75 h. The systemic bioavailability was 95.20%. Amikacin was detected in liver and kidney for 5 days post a single IM injection and withdrawal time was 6 days.
Authors and Affiliations
Dr. Mohamed Aboubakr
Keywords
Related Articles
- EP ID EP617514
- DOI -
- Views 228
- Downloads 0
REVIEW ON ANTIDIABETIC DRUGS
Diabetes insipidus is the disorder that causes an imbalance of water in the body. The major complication is the dehydration leads to electrolyte imbalance. Following drugs desmopressin, vasopressin and hydrochlorothazide...
ELECTROCHEMICAL SENSOR BASED ON THE CARBON PASTE ELECTRODE MODIFIED WITH POLYMER FOR DETERMINATION OF COPPER IONS
In this work, we have studied the performance of carbon past electrodes (CPE) coated with £ - caprolactone polymer composites was investigated as an electrochemical sensor in the determination of Cu2+ ions in a 0.1M NaCl...
ANTIOXIDATIVE POTENTIALS OF COOKED BAMBARA GROUNDNUT BASED DIET (VIGNA SUBTERRANEAN) ON LIPID PEROXIDATION STATUS IN PRETREATED ALLOXAN INDUCED DIABETIC RATS
The present study examines the antioxidant potentials of Cooked Bambara groundnut (Vigna subterranean) based diet in pretreated alloxan induced diabetic rats. Thirty (30) male albino rats (Rattus novergicus) were ramdoml...
IMPROVING THE PERFORMANCE OF EGYPTIAN CLAY FOR USING AS DRILLING FLUIDS
Bentonite clay is the main component of the water based mud. This paper represents composition and treatment capability of clays collected from the claystone quarries located in Kom Oshim area, El-Fayoum province, Egypt...
THE ROLE OF HYPOXIA AND HIF-1Α ON MESENCHYMAL STEM CELLS; POTENTIAL THERAPEUTIC ADVANTAGES & HAZARDS
Stem cells can proliferate, differentiate and renew themselves. Mesenchymal stem cells (MSCs) are proving to be the most promising source for supply of stem cells in regenerative medicines. To produce therapeutic efficac...