PHARMACOKINETICS SURVEILLANCE ON DRUGS- A REVIEW
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 6
Abstract
All drugs can have negative effects. When they reach the market, there are reasonably safe, yet remain in surveillance by pharmacovigilance. Pharmacokinetics plays a very important role in this because we can have monitored the ranges of concentrations of pharmacologic active principles. With these results, we calculate pharmacokinetic parameters and ranges of concentrations and with this information, we can determinate if the treatment is ineffective and above. It is frequent that toxic effects are observed. However, there are patients who respond to levels below this range and others need levels above this. For the determination of serum levels of a drug is justified it is necessary that there is a reliable analytical method that allows its determination, that there is a poor relationship between administered doses and levels and that there is a good relationship between the serum levels of the drug and its therapeutic or toxic effects i.e., an optimal interval. Variability in the response to drugs depends on multiple pharmacokinetic factors, which modify the plasma levels, and pharmacodynamic factors that alter the sensitivity to a certain level. In addition, the prescribed dose may be different from the taken by the patient by errors in the administration or therapeutic non-compliance.
Authors and Affiliations
Dr. Gilberto Quiñonez Palacio
Keywords
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