Pharmacological evaluation of 2-chloro substituted thiophene compound for antiinflammatory activity in rats
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2014, Vol 2, Issue 1
Abstract
Introduction: Inflammation is a phenomenon associated with almost every disease process. It has always been a challenge to halt the inflammatory process with various drugs and to identify a drug with least side effects. In this study, 2-chlorothiophene was evaluated for its anti-inflammatory activity as an attempt in pursuit for a new ideal agent. Methods: Wistar albino rats were used in the study. Anti-inflammatory activity for acute phase was assessed by carrageenan induced paw edema model and cotton pellet induced granuloma model for chronic inflammation. Results: 2-chloro thiophene showed significant dose dependent anti-inflammatory action. At 20 mg/kg dose, it showed 84.62 % reduction in edema volume in acute phase which was superior to indomethacin. In chronic model the test drug at 20mg/kg showed 27.73% reduction in cotton pellet induced granuloma weight. The results were statistically significant with P<0.05. Conclusions: 2-chloro thiophene was found to possess significant anti-inflammatory properties for both acute and chronic inflammation and can be a promising anti- inflammatory agent.
Authors and Affiliations
Niroop Revannasiddaiah*| Assistant professor, Department of pharmacology, PES Institute of Medical Sciences and Research, India., Surendra Kumar Gondi| Medical officer, Chittoor, India., Muruganathan Gopal| Assistant Professor, Department of Pharmacognosy, P. E. S College of Pharmacy, Bangalore, India., Revanna Swamy Ankaiah| Professor, Department of Pharmacology, PES Institute of Medical Sciences and Research, India., Muralidhar Pyati| Professor and HOD, Department of Pharmacology, Professor and HOD, Department of pharmacology, India.
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Pharmacological evaluation of 2-chloro substituted thiophene compound for antiinflammatory activity in rats
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