Pharmacological evaluation of anti-Diabetic activity of Pungampoo Chooranam on Streptozotocin induced diabetic rats.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 11
Abstract
The Traditional Siddha system of medicine has a vast documentation of herbs in its ancient literature for the treatment Neerizhivu/Madhumegham (Diabetes milletus). Many of these formulations are clinically effective but they lack in scientific evidence which is the chief present day challenge faced by the traditional system of medicine. Pungampoo Chooranam is one such formulation which has been indicated for the treatment of diabetes millets in the Siddha Classical literature Boga Munivar Vaithiyam – 700. The present study was aimed to screen the oral antihyperglycemic activity of Pungampoo Chooranam (PC ) (200 and 400 mg/kg) against streptozotocin (45 mg/kg i.p.) induced diabetes mellitus in rat models. The animals were grouped into four groups of 6 animals each. Group I (Control group)-received normal saline, Group II rats were administered with 45 mg/kg,i.p of STZ, Group III received 45 mg/kg,i.p of STZ + 200mg/kg of Pungampoo Chooranam and group IV received 45 mg/kg,i.p of STZ + 400mg/kg of Pungampoo Chooranam. The Trial drug Pungampoo Chooranam (PC) was administered for 28 consecutive days, and the effect of the investigational drug was studied on Body weight Changes, blood glucose levels, HbA1C levels, Insulin levels, Blood urea and creatinine levels at regular intervals. The study results were statistically analysed by Welch's ANOVA and paired t test . The study results revealed that the Siddha drug Pungampoo Chooranam had significant antidiabetic effects.
Authors and Affiliations
J. Nisha
Keywords
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