Abstract

Notwithstanding the high cardiovascular risk, facts of efficacy of preventive strategies in individuals with diabetes are limited. In particular, the recommendations in the use of aspirin in patients with diabetes mostly reflect an extrapolation from data deriving from other high risk populations. In addition, the supposed additive effects of aspirin and statins in diabetes remain to be investigated. This aspect is of particular interest in the light of the existing debate concerning the need of multiple interventions to reduce total cardiovascular risk, which has also lead to the proposal of a polypill. This review is to evaluate the efficacy of aspirin in the primary prevention of major cardiovascular events in diabetic patient’s candidate for treatment of statins. These preventive strategies will be evaluated on the top of the other strategies aimed at optimizing the care of diabetic patients in terms of metabolic control and control of the other cardiovascular risk factors.

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