PHENYTOIN INDUCED TOXIC EPIDERMAL NECROLYSIS; A CASE REPORT
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2017, Vol 6, Issue 3
Abstract
Several drugs are at high risk of causing Toxic Epidermal Necrolysis (TEN) including Anti-convulsants such as phenytoin, carbamazepine and phenobarbital. Other drugs include antimicrobials like sulfonamides followed by Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and anti-gout drugs.1 We are presenting a case of 60 year old female patient with Phenytoin induced TEN. Who had a history of cranial surgery 3 weeks prior to admission and prescribed with discharge medications of phenytoin, diclofenac and dexamethasone. After 3 weeks of treatment, patient has developed oral and genital erosions with itchy vesicles and bullae all over the body and admitted to tertiary care hospital with complaints of burning sensation on chest and pedal edema and hematuria for 3 days. Phenytoin induced TEN was suspected and was admitted from causality. The patient was managed aggressively with steroids, higher antibiotics and creams (over the lesion), nutritional supplement was taken care of and palliative care was given. The patient expired due to septic shock and multiple organ dysfunctions with metabolic acidosis after 8 day of admission. This case highlights the importance of Phenytoin possibly causing TEN. Government of India and Regulatory Authorities should create awareness among practitioners to report all the ADRs to concerned ADR Monitoring Centers.
Authors and Affiliations
Merphin Philip Thomas*| Pharm.D, Krupanidhi College of Pharmacy, Chikka Bellandur, Carmellaram Post, Varthur Hobli, Bangalore-35, Miriam Lalmuanpuii Hnamte| Pharm.D, Krupanidhi College of Pharmacy, Chikka Bellandur, Carmellaram Post, Varthur Hobli, Bangalore-35, Sina Zare| Pharm.D, Krupanidhi College of Pharmacy, Chikka Bellandur, Carmellaram Post, Varthur Hobli, Bangalore-35, Teena Nazeem| Assistant Professor, Krupanidhi College of Pharmacy, Bangalore, Karnataka, 560035
Keywords
Related Articles
- EP ID EP3860
- DOI -
- Views 440
- Downloads 24
FORMULATION & CHARACTERIZATION OF TOPICAL GEL CONTAINING SANDALWOOD OIL OF NAPROXEN FOR THE TREATMENT OF RHEUMATOID ARTHRITIS
The present research study is based on development of a topical gel formulation of naproxen containing sandalwood oil. The oral administration of naproxen comes with potential gastrointestinal disorders which can be avoi...
GENDER DIFFERENCES IN AIRWAY DYNAMICS IN HEALTHY NONSMOKING LIBYAN MEDICAL STUDENTS
Some of the respiratory structures and functions vary with the gender. Only 2-3 parameters of the forced vital capacity (FVC) were studied earlier in both sexes in Libyan population. In the present study, we have measur...
FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILMS OF FLUVASTATIN SODIUM BY USING TASTE MASKING TECHNIQUES
Fluvastatin sodium, a HMG-COA reductase inhibitor has shorter half life (1.2). It undergoes extensive first pass metabolism, frequent dosing is required in case of conventional dosage form. It is an bitter drug so an att...
INSOMNIA WITH HOMOEOPATHY
Most people encounter sleep difficulties from time to time, often related to stress or pain. Many of these bouts get better without treatment. Unfortunately, in a significant proportion of the population, sleep problems...
SOLUBLITY ENHANCEMENT OF FLUCONAZOLE BY FORMULATION OF HYDROTROPIC SOLID DISPERSIONS
In the present research work mixed hydrotropic solubilization phenomenon is used to enhance the solubilization of poorly water soluble drugs. Bulk drug samples were identified by the observed IR spectra and the melting p...