Phytochemical Studies of Different Fractions of Galega officinalis Extract and Their Effects on Some Biochemical Parameters in Alloxan-Induced Diabetic Rats
Journal Title: European Journal of Medicinal Plants - Year 2017, Vol 19, Issue 1
Abstract
Galega officinalis Linn (Goat’s rue) is popularly called sakpani in Hausa speaking part of Nigeria. The Plant belongs to the family Leguminoseae. G. officinalis is chiefly used as an antidiabetic plant because of its ability to reduce blood sugar levels. The plant has positive effect on breast-milk production. Aqueous, methanolic, ethanolic and acetone extracts of the plant Galega officinalis Linn (Leguminoseae) and fractionations of the methanolic extracts were carried out in stages using standard procedures. Alkaloids, glycosides and flavonoids from the methanolic extracts of G. officinalis at 400 mg/kg body weight significantly (p<0.05) reduced the plasma glucose concentration in diabetic treated rats at the 3rd and 28th day of treatment when compared to diabetic untreated rats with alkaloids, glycosides and flavonoids producing 81.61%, 27.20% and 21.76% decreases in glucose concentrations. Also alkaloids from the methanolic extracts of G. officinalis improved lipid profile and reverse the adverse effects of induced diabetic on selected marker enzymes. Methanolic fractions F1, F2, F3 and F6 produced remarkable effect by decreasing glucose concentration in diabetic treated rats compared to diabetic untreated rats. Methanolic extract of G. officinalis proved to be a rich source of phytochemicals with potent hypoglycaemic and hypolipidemic effects.
Authors and Affiliations
C. D. Luka, G. I. Adoga, G. Istifanus
Keywords
Related Articles
- EP ID EP326966
- DOI 10.9734/EJMP/2017/32145
- Views 121
- Downloads 0
Bioassay-Guided Discovery of Antibacterial Agents: In vitro Susceptibility of Multi-drug Resistant Staphylococcus aureus to Psidium guajava Linn Extracts
Aims: Development of multi-drug resistance to antibiotics is a major health concern worldwide. This study assessed the antibacterial activities of leaves extracts from Psidium guajava against multi-drug resistant Staphy...
Biological Activities of the Hydro-alcoholic and Aqueous Extracts of Achillea falcata L. (Asteraceae) Grown in Jordan
Aim: This study aimed to screen the aqueous and hydro-alcoholic extracts of Achillea falcata L. (Asteraceae) grown in Jordan for their antioxidant, antibacterial, antiplatelet and anti-proliferative efficacy. Study Desig...
Unearthing the Medicinal Properties of Tillandsia recurvata (Ball Moss): A Mini Review
Background: More than half of traditional medicines are of natural origin and research has shown that these are associated with fewer side effects than the synthetic ones, since less than 10% of the 350,000 identified pl...
Evaluation of the Acute and Sub-acute Toxicity Effects of Ethanolic Leaves Extract of Lagenaria brevifolia (Bitter gourd) on Hepatic and Renal Function of Rats
Aim: Dearth of information exists on the phytochemistry and toxicity profile of ethanolic leaves extract of Lageneria breviflora in spite of the much touted medicinal efficacy of the plant. The present study qualitativel...
Antimicrobial Activities of Six Selected Plants against Multi-drug Resistant Staphylococcus aureus
The problem of microbial resistance is growing and the outlook for the success of antimicrobial drugs in the future is still uncertain. For a long period, plants have been a valuable source of natural products for mainta...