Plasma Lysophasphatidic Acid Level: A Diagnostic Tool and Benchmark for Ovarian Cancer Management
Journal Title: Open Access Journal of Oncology and Medicine - Year 2018, Vol 1, Issue 5
Abstract
In ovarian cancer there is formation of tumor cells in ovarian tissues. Lysophosphatidic acid (LPA) motivated cell proliferation, migration and endurance by acting on its cognate G-protein-coupled receptors. Lysophosphatidic acid (LPA), present in ascitic fluid, motivates the enlargement of malignant ovarian tumors by raising the appearance of vascular endothelial growth factor (VEGF) in ovarian cancer cells. Ovarian cancer cell progress is repressed by alendronate, a nitrogen containing biophosphate which attenuate the establishment of Rho by blocking the mevalonate pathway. In ovarian cancer there is formation of tumor cells in ovarian tissues. In the US, in about 69 women 1 woman will build up this malignancy during her life span. And, not only this disease occurs in women over the age of 50 but also in women with younger ages [1]. There are many different types of ovarian tumors. Few of them comprise: Ovarian (it is mainly extensive type of ovarian tumor), Ovarian germ cell tumor and Low malignant potential ovarian tumor [2]. Plasma LPA levels may demonstrate that it is a potential biomarker for ovarian cancer and other gynecologic cancers [3]. Significantly high total LPA levels were resolute in the sera of patients with diverse types of tumors benevolent (benign) and wicked (malignant) [4]. Lysophosphatidic acid (LPA), lysophosphatidylinositol (LPI), lysophosphatidylcholine (LPC), and sphingosine-1-phosphate (S1P) appear useful as investigative and predictive biomarkers of ovarian cancer [5].
Authors and Affiliations
Muhammad Imran Qadir, Saima Saadat
Keywords
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- EP ID EP587867
- DOI 10.32474/OAJOM.2018.01.000122
- Views 65
- Downloads 0
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