Repurposed Drugs and Nutraceutical Supplements as Neglected Complements to Cancer Treatment
Journal Title: Open Access Journal of Oncology and Medicine - Year 2018, Vol 1, Issue 5
Abstract
In ovarian cancer there is formation of tumor cells in ovarian tissues. Lysophosphatidic acid (LPA) motivated cell proliferation, migration and endurance by acting on its cognate G-protein-coupled receptors. Lysophosphatidic acid (LPA), present in ascitic fluid, motivates the enlargement of malignant ovarian tumors by raising the appearance of vascular endothelial growth factor (VEGF) in ovarian cancer cells. Ovarian cancer cell progress is repressed by alendronate, a nitrogen containing biophosphate which attenuate the establishment of Rho by blocking the mevalonate pathway. Cancer is still one of the major problems found in medical practice and in spite of clear advances in diagnosis and treatment, it remains an important cause of suffering and death in human and veterinary pathology. So there is a need to search for new approaches and ideas in this field. As of January 1, 2014, there were 14.5 million estimated survivors of the 10 most prevalent cancer sites among males and females in the United States [1]. One in four Americans will die of cancer [2] in the next years. Prevention, early diagnosis, surgery, radiotherapy, chemotherapy, immunotherapy and targeted drugs have made substantial contributions, and will continue to do so in the foreseeable future. But there is more that can be done. Since cancer is a very complex disease, it is reasonable to think that future solutions can only emerge from very sophisticated and expensive research. However, we dare to suggest that, right now, there are simple approaches that may be quite useful as complementary treatments in the management of cancer, just by re-positioning or repurposing, already approved existing drugs.
Authors and Affiliations
Tomas Koltai
Keywords
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- EP ID EP587879
- DOI 10.32474/OAJOM.2018.01.000123
- Views 57
- Downloads 0
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