PLATELET RICH PLASMA IN ANDROGENIC ALOPECIA IN MALE AND FEMALE PATIENTS- A MYTH, A PROSPECTIVE STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 21
Abstract
BACKGROUND Androgenetic alopecia (AGA) is a hereditary, androgen-dependent dermatological disorder more common in men. It is occasionally seen in women. It commonly begins by 20 years of age and affects nearly 50% of men by the age of 50 years. It is a progressive thinning of the scalp hair in a defined pattern causing significant lowering of the self-esteem and psychological well-being of the patient. The treatment modalities are limited, mainly minoxidil, 5-alpha-reductase inhibitors and hair transplantation. Few treatment options and those too having side effects prompted the discovery of platelet-rich plasma (PRP). (1) The basic idea behind PRP injection is to deliver high concentrations of growth factors to the scalp with the hope of stimulating hair regrowth. PRP is an autologous preparation of platelets in concentrated plasma. Although, the optimal PRP platelet concentration is unclear, the current method by which the PRP is prepared reports 300 - 700% enrichment with platelets concentration consequently increasing to more than 1,000,000 platelets. PRP has attracted attention in several medical fields, because of its ability to promote wound healing. (2) Activation of alpha granules of platelets releases numerous proteins including platelet derived growth factor (PDGF), transforming growth factor (TGF), vascular endothelial growth factor (VEGF) and interleukin (IL-1). It is hypothesised that growth factors released from platelets may act as a stem cell in the bulge area of the follicles stimulating the development of new follicles and promoting neovascularisation. Aims and Objectives- This is uncontrolled clinical trial done to know the safety, efficacy and feasibility of PRP injections in treating androgenic alopecia in both male and female patterns hair loss. MATERIALS AND METHODS This study was uncontrolled clinical trial. A total of 32 patients were selected, out of which 18 patients suffering from hair loss due to androgenic alopecia (56%) and 14 cases of female pattern hair loss (44%) not responding to 6 months treatment with minoxidil and finasteride were included in the study. A total volume of 2 to 3 cc of PRP was injected in the scalp using an insulin syringe. The treatment was repeated every 2 weeks for a total of 4 times. The outcome was accessed after 3 months by clinical examination, by taking photos and doing hair pull test. Study Setting- DVL Department, Andhra Medical College, King George Hospital, Visakhapatnam, Andhra Pradesh, India. RESULTS A significant reduction of hair loss was observed between 1st and 4th injection. There was significant improvement in the hair growth after 6th injection in 22 patients and hair pull test became negative in 13 of the above cases. CONCLUSION PRP is a single, cost effective and feasible treatment option for androgenic alopecia. In both male and female patterns, it showed good results.
Authors and Affiliations
Jhansi Lakshmi S. , Dhanya Sri, Rupa Ramani J, Shaik Asha, Naveen Kumar, Sameera Sameera, Amrutha Bindhu, Hanusha Hanusha
Keywords
Related Articles
- EP ID EP431596
- DOI 10.14260/jemds/2018/567
- Views 107
- Downloads 0
QUALITY ASSESSMENT OF REPRODUCTIVE AND CHILD HEALTH SERVICES IN KAMRUP DISTRICT OF ASSAM
BACKGROUND The provision of good quality care is the main thrust of the RCH programme. Greater emphasis is given to better quality of services as compared to the previous National Family Planning Programme. Objectives- 1...
ROLE OF ULTRASOUND AS AN IMAGING MODALITY IN THE UTERINE MASSES IN A TERTIARY CARE HOSPITAL
BACKGROUND In the preoperative diagnosis and management of patients with gynaecologic pelvic masses, gray scale ultrasound or computed tomography can provide significant clinical data.[1] Accurate evaluation of uterine a...
COMPARATIVE STUDY OF DIAGNOSTIC EFFICACY OF FNAC, HR-USG & MAMMOGRAPHY IN PALPABLE BREAST LUMP
BACKGROUND With growing awareness and increasing literacy, people have now become more conscious about problems related to breast. The commonest mode of presentation of diseases of the breast is "lump" or a “palpable mas...
FATAL AND RECURRENT METHEMOGLOBINEMIA AFTER INGESTION OF PRINTING REDUCER DYE (NITROBENZENE)
Nitrobenzene, a pale yellow oily liquid with an odour of bitter almonds is used as intermediate in the synthesis of aniline dyes, and as a solvent for the manufacture of cellulose ethers and acetate, as a flavo...
TRENDS IN AETIOLOGY AND SUSCEPTIBILITY PATTERN OF BACTERIAL PATHOGENS FROM BLOODSTREAM INFECTIONS AT A TERTIARY CARE TEACHING HOSPITAL IN WESTERN MAHARASHTRA- A 4-YEAR ANALYSIS
BACKGROUND Bloodstream infections (BSIs) are life-threatening. Microbiological cultures take time for reporting. It is essential to start initial appropriate empirical treatment to reduce morbidity and mortality due to s...