Post Operative Analgesia after Vaginal Hysterectomy under Spinal Anaesthesia: A comparative study between Gabapentin and Pregabalin
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 2
Abstract
Introduction: Failure to provide postoperative pain relief is morally and ethically unacceptable. The aim of present study was to evaluate post- operative analgesic benefit in patients administered pregabalin or gabapentin as premedication for surgery under spinal anaesthesia for vaginal hystrectomy and to compare their postoperative efficacy with respect to duration of analgesia, total post- operative requirements of analgesics and to study the side effects and complications attributable to these drugs. Material and Methods: This prospective randomized study was conducted after ethical clearance where single dose of Gabapentin (900mg) was compared with Pregabalin (300mg) given to patients preoperatively. In this study 60 patients were scheduled for vaginal hysterectomy with 30 patient in each group ranging from 30-60 years in grade I and II of American Society of Anaesthesiologist’s (ASA) classification.Time from Spinal to rescue analgesia (in minutes), rescue analgesic consumption and complications was recorded in 24 hours post operatively. Data were analysed using SPSS ® 16.0 (software version, USA). Two sample paired T-Test was used to find out significance between two samples. Data was reported as mean value ±S.D. A P-value of < 0.05 was considered statistically significant. Results: The group G and group P were comparable with respect to demographic characteristics like age, weight, ASA physical status and duration of surgery. The total postoperative analgesic duration i.e. time from spinal analgesia to first dose of analgesic was 245.46± 7.42 mins in Group G whereas 366.1± 9.11mins in Group P, which was highly significant (P < 0.00). Mean dose of analgesic given in first 24 hrs was lower in group P 102.96 ±5.32 mg as against 176.26±19.31 mg in group G which was statistically significant (P<0.00). Conclusion: Gabapentin and pregabalin had significant effect in relieving postoperative pain when given preemptively. Pregabalin has superior efficacy with respect to quality and duration of analgesia when compared with gabapentin.
Authors and Affiliations
Mukesh Kumar Prasad, Kanchan Rani
Keywords
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