Preemptive analgesia in patients undergoing infraumbilical laparotomy under spinal anesthesia: A randomized, double-blind, comparative evaluation of varying doses of oral pregabalin
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 10, Issue 3
Abstract
Background:Pain is the foremost complaint in majority of patients following surgery. Eventhough, several studies have reported the effectiveness of preemptive pregabalin, its optimal dose for reducing acute post-operative pain is still a mystery. Hence, this study was conducted to evaluate the ideal preemptive analgesic dose of pregabalin.Methods:In this prospective, double-blind, parallel-group, randomized trial, 44 patients undergoing spinal anesthesia for infraumbilical laparotomy were randomized into 2 groups:Group A received 75mg of oral pregabalin, whereas Group B received 150mg of oral pregabalin, onehourpreceeding spinal anesthesia. Visual Analogue Scale was used for the assessment of pain, post-operatively.Results:The mean time to first VAS> 3 was 540 ± 178.99 min in Group A, while in Group B was 665.71 ± 266.24 min with no statistically significant difference noted. The average dosage of diclofenac given during the first 24 hours post-operatively in Group A was 220.81 ± 45.63 mg and 203.71 ± 51.11 mg in Group B, which was also statistically similar. But a statistically significant increase(P =0.001*) was observed in the mean time taken to two segment regression in sensory blockade, in Group B (174.14±13.9 min) when compared to Group A (157.29±12.06 min). Ramsay sedation score 3 was noticed in eight patients in Group B and only in four patients in Group A.Conclusion:Preemptive oral pregabalin 75mg and 150 mg are equally effective in providing good post-operative analgesia, but pregabalin 75 mg may be an ideal choice considering lesser side effects.
Authors and Affiliations
Derlin Thomas, Betsy Varghese, Manu Sam Mathew, George Kanjirathummoottil George
Keywords
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- EP ID EP616937
- DOI 10.26611/10151039
- Views 161
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