PRELIMINARY INVESTIGATIONS INTO THE PHYSICOCHEMICAL AND COMPACTION CHARACTERISTICS OF MODIFIED STARCH OF DISCOREA ALATA USING DICLOFENAC SODIUM TABLET
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 10, Issue 7
Abstract
Objective: This work focused on evaluating the micromeritic and compressional properties of pregelatinized African water yam (Discorea alata) starch and its modified forms with comparison to pregelatinized corn starch and microcrystalline cellulose.Methods: Two modifications of the water yam starch were prepared; acetone dehydrated pregelatinized form (DSA) and an admixture of DSA and pregelatinized corn starch (CDSA). A third form of starch is the acetone dehydrated pregelatinized corn starch (CSA). These were used to form batches compacted as tablets using diclofenac sodium as the active moiety. Physicochemical and flow characteristics of the starch powders were elucidated, and the drug starch compatibility studies done using the Fourier transform Infra-red (FTIR) technique. Compaction studies were investigated on tablets formed at different compression pressures and Heckel plots were prepared.Results: The slope of the straight line (K) of 0.8959 was greatest for F1 while yield pressure (Py) value of 10.965 was highest for F3. These values from the Heckel plot suggest that while the tablets of control batch of microcrystalline cellulose (F4) and a batch of pregelatinized corn starch (F2) formed harder compacts, less likely deformed plastically, the Discorea alata batch (F1) and the admixed batch (F3) were likely to deform plastically. Also, the binding efficiency of the compact was significantly high (47.81%Kgscm-1) for F4 at 56.5Kpas compaction pressure, higher than that obtainable for any of the other formulations at the compaction pressures under consideration. All starches formed had similar moisture content (of 10%) despite the different sources but the interaction between the water molecule and pregelatinized water yam starch improved as revealed by viscosity(7.18mPas), hydration capacity(3.27%) and swelling index (250%) of CDSA.Conclusion: It could be concluded that pregelatinized water yam starch could be used as a substitute for corn starch or microcrystalline cellulose as a pharmaceutical excipient (binder/filler) in tablets formulation.
Authors and Affiliations
Timma O Uwah, Ekaete I Akpabio, Daniel E Ekpa, Akwaowo E. Akpabio, Jacob Godwin
Keywords
Related Articles
- EP ID EP566221
- DOI 10.22159/ijpps.2018v10i7.23730
- Views 58
- Downloads 0
A NEW NAPHTHOQUINONE ISOLATED FROM POLYGONUM MULTIFLORUM (POLYGONACEAE)
Objective: This research is mainly focused towards isolation and structural elucidation of pure compounds from the extract and fractions of Polygonum multiflorum through silica gel column chromatography.Methods: The air...
FACTORS AFFECTING POSTPARTUM DEPRESSION AMONG WOMEN OF THE UAE AND OMAN
Objective: Is to evaluate factors related to the development of postpartum depression among an United Arab Emirates and Omani societies.Methods: The study was prospective, observational, and descriptive using a self-repo...
PROPERTIES OF GUAR GUM - DEAD SEA SALT (GG-DSS) MEDICATED GEL
Objective: The main objective of this study is to understand the viscoelastic nature of Guar Gum - Dead Sea Salt (GG-DSS) based polymeric gel, a semisolid product; which is prepared with all natural ingredients to achiev...
IN VITRO ANTIOXIDANT ACTIVITIES FROM VARIOUS EXTRACTS OF BANANA PEELS USING ABTS, DPPH ASSAYS AND CORRELATION WITH PHENOLIC, FLAVONOID, CAROTENOID CONTENT
Objectives: The objectives of this research were to study antioxidant capacity from various extracts of banana peels using two methods of antioxidant testing which were ABTS (2.2’-azino-bis (3-ethylbenzthiazoline-6-sul...
EVALUATION OF HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF PELLIONIA HEYNEANA WEDD. LEAF ETHANOLIC EXTRACT ON CARBON TETRACHLORIDE INDUCED LIVER DAMAGE IN WISTAR RATSEVALUATION OF HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF PELLIONIA HEYNEANA WEDD LEAF E
Objective: The aim of the study was to investigate the antioxidant and hepatoprotective activity of Pellionia heyneana Wedd. leaf ethanolic extract.Methods: The antioxidant potential of the extract was studied by DPPH an...