PRELIMINARY PHYTOCHEMICAL SCREENING, ANTIBACTERIAL AND ANTIOXIDANT ACTIVITIES OF COMMELINA NUDIFLORA (COMMELINACEAE)
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 11
Abstract
The present study was carried out to study the antibacterial and antioxidant activities of Commelina nudiflora extracts and to analyze the extracts for secondary metabolites. Chloroform, acetone and ethanolic extracts of Commelina nudiflora were screened for tannins, phlobatannins, saponins, flavonoids, terpenoids, cardiac glycosides, and steroids. Antibacterial activity was carried out by Minimum Inhibitory Concentration (MIC) and antioxidant assay was carried out using 1,1-diphenyl picrylhydrazyl (DPPH) and total antioxidant activity. Flavonoids present in all extracts. Acetone and ethanolic extracts exhibited antibacterial activity. All extracts showed significant antioxidant activity. All extracts showed concentration dependent antioxidant activity. Ethanolic extract showed high antioxidant activity against DPPH with IC50 11.25 mg/ml. The total antioxidant activity was high in chloroform extract with IC50 0.1282 mg/ml. The results show Commelina nudiflora has potential antioxidants that can fight against life threatening diseases like inflammation, cancer etc.
Authors and Affiliations
Suganya Anto , Jeya Jothi
Keywords
Related Articles
- EP ID EP152980
- DOI 10.7897/2230-8407.0511174
- Views 88
- Downloads 0
IN VITRO EVALUATION OF ANTIOXIDANT ACTIVITY OF SKIMMIA ANQUETILIA LEAVES EXTRACTS
The purpose of the present study is to evaluate in vitro antioxidant and free radical scavenging potential of different organic and aqueous fractions of Skimmia anquetilia Tayl. Initially the phytochemical constituents o...
LONG-TERM SAFETY AND TOLERABILITY OF FENTANYL CITRATE NASAL SPRAY IN THE TREATMENT OF BREAK THROUGH CANCER PAIN (BTCP) IN SUBJECTS TAKING REGULAR OPIOID THERAPY
An ideal patient-controlled analgesic (PCA) opioid would have rapid onset and longer duration of action when compared to the currently existing opioids including morphine. The purpose of this study was to verify the effi...
A RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF MONTELUKAST SODIUM IN BULK AND PHARMACEUTICAL DOSAGE FORMS
A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of Montelukast Sodium in pharmaceutical dosage form. Isocratic elution at a flow rate of 1.2 mL min -1 was empl...
EVALUATION OF ANTICONVULSANT ACTIVITY OF ALCOHOLIC EXTRACT OF BENINCASA HISPIDA (THUNB) COGN. FRUIT EXTRACTS
Epilepsy is a common neurological condition, affecting 0.5 to 1% of the population worldwide. According to the Sanskrit texts, Benincasa Hispida fruit is useful in insanity, epilepsy, constipation, piles dyspepsia and ot...
IN VITRO α-AMYLASE AND α-GLUCOSIDASE INHIBITORY EFFECTS OF ETHANOLIC EXTRACT OF EVOLVULUS ALSINOIDES (L.)
Diabetes mellitus is a disorder in carbohydrate metabolism of endocrine system due to an absolute or relative deficiency of insulin secretion, action, or both. There has been an enormous interest in the development of al...