Preparation and biocompatibility evaluation of composite nanofibers with TiO2 nanoparticles
Journal Title: Advanced Journal of Chemistry-Section A (Theoretical, Engineering and Applied Chemistry) - Year 2019, Vol 2, Issue 3
Abstract
Medical device industry is growing at a very fast pace and a lot of activities have recorded over the past decade. Hence, it is very important the choice of blood compatible materials for use in the implants and medical research. In this work, chitosan (CS)/poly (ethylene oxide) (PEO) /TiO2 composite nanofibers was prepared. Then, morphology of nanofiber determined by scanning electron microscopy (SEM) and size of mean diameter of fibers are measured by Image J software. Optimum conditions of nanofiber producing are; voltage: 24 kV, output debi: 0.2 milliliters per hour and distance: 15 cm. Diameter of nanofibers produced is 88.65 nm. Also, FT-IR spectroscopy was used to evaluate the functional groups of nanofiber and ensure interaction between CS/PEO with nano TiO2. Swelling and degradation of these nanofibers are tested in acetate buffer solution (pH=7. 4, temperature= 37 °C) in 1 week. The hemo compatibility tests that performed on these nanofibers were hemolysis, PT and PTT tests. In addition, the antibacterial activity of CS/PEO/TiO2 against Staphylococcus epidermidis, the main cause of implant infections, is studied. The results represent that the hemolysis ratio of samples are well under 1%. Therefore, CS/PEO/TiO2 nanofibers have an excellent hemo compatibility and can be used for medical applications
Authors and Affiliations
Minoo Sadri, Maryam Ahmadi Beni
Keywords
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- EP ID EP479194
- DOI 10.29088/SAMI/AJCA.2019.2.256270
- Views 86
- Downloads 0
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