The objective of the present investigation was to prepare and characterize a contraceptive vaginoadhesive Propranolol hydrochloride gel. To achieve this various mucoadhesive polymers including Na CMC (1-4% w/w) and tragacanth gum (1-4% w/w) were dispersed in an aqueous-based solution containing the drug (0.5% w/w). The mucoadhesive properties of the gels were assessed on sheep vaginal mucosa in citrate phosphate buffer pH 4 at 37°C. Formulations containing charged functional groups in their polymeric structure showed higher mucoadhesive strengths in comparison to those composed of neutral polymers. In vitro drug release profiles of the gels were determined in citrate phosphate buffer pH 4. Results indicated that formulation F4 (containing Na CMC 4% w/w) released the drug over 54 hrs with a burst release at the initial phase followed by a sustained release pattern. The formulation showed good bioadhesive strength (24.6±0.05 gm). The %yield was found to be 95.3±0.02. In conclusion formulation F4 was considered as the most desirable formulation as it exhibited appropriate mucoadhesive properties while having the potential of providing a prolonged drug release which is assumed to render longer contraceptive efficacy.