Preparation and Characterization of sPLGA Complex Microspheres as a Promising Carrier for Cucurbitacin B
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 9, Issue 6
Abstract
The purpose of this research was to develop a new kind of GA-CS/sPLGA complexed Microspheres delivery system for CuB. In this work, star-shaped poly(lactic-co-glycolic acid) (sPLGA-COOH) and chitosan modified with glycyrrhetic acid (GA-CS) were successfully synthesized. The GA-CS/sPLGA complexed Microspheres for CuB was prepared by emulsion evaporation method. Futhermore, CuB-loaded Microspheres formulations were optimized. The release behaviour of CuB-loaded Microspheres in vitro were also examined. It was showed that CuB-loaded amount of Microspheres could reach 58.78%±1.288 by adding GA-CS into the external water phase. The size of corresponding CuB-loaded Microspheres was 370±16.14 nm in diameter, and zeta potential was negative 10.86±0.4790 mV measured by laser light particle size/zeta potential analysis. The results indicated that the complexed GA-CS/sPLGA Microspheres raised the entrapment efficiency for CuB. In vitro drug release demonstrated that complexed GA-CS/sPLGA Microspheres had many advantages such as sustained release and low initial drug burst.
Authors and Affiliations
Yi Zhang, Yue Liu, Hewei Shao, Xiaoyan Han
Keywords
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- EP ID EP342379
- DOI 10.9734/BJPR/2016/22575
- Views 95
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