Solubility Enhancement of a BCS Class II Drug Using Granulated Fumed Silica as an Adsorbent
Journal Title: Journal of Pharmaceutical Research International - Year 2017, Vol 18, Issue 6
Abstract
Aim: The aim of this study was to improve solubility and dissolution characteristics of Ibuprofen using granulated fumed silica (Aeroperl®300) as a carrier. Methods: Ibuprofen-silica complex was prepared by solvent evaporation technique using ethanol as the solvent. Formulation I and II consisted of polymers hydroxypropyl methylcellulose (HPMC E5) and Polyvinyl Pyrrolidone (PVP K-30) respectively. Each formulation was prepared using 1:1:1 and 1:1:2 ratio of drug, polymer and silica. Dried powder obtained was characterized using Differential Scanning Calorimetry (DSC), Powder X-Ray Diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR) and Polarized Light Microscopy (PLM). In-vitro dissolution studies were carried out using three different media including Phosphate buffer (pH 6.8), 0.1N Hydrochloric Acid (pH 1.2) and de-ionized water. Results: Drug loading up to 30% w/w was successfully achieved with 1:1:1 ratio formulations. Physical characterization data confirmed change of crystalline Ibuprofen into amorphous form after processing. Maximum solubility increment of 33-37% was achieved in Phosphate buffer with formulations II A and II B within the first 5 minutes of dissolution as compared to the control (pure drug). Conclusion: Enhancement in drug solubility and subsequent dissolution rate can be attributed to adsorption of amorphous drug molecules onto porous silica that readily desorb on contact with dissolution media. High porosity and huge surface area of silica makes it a potential candidate for improving delivery of poorly soluble drugs.
Authors and Affiliations
Sawani D. Talekar, Rutesh H. Dave
Keywords
Related Articles
- EP ID EP313080
- DOI 10.9734/JPRI/2017/36872
- Views 87
- Downloads 0
Human Drug Targets Identification in Breast Cancer by Computationally Based DNA Microarray Analysis
Aims: The availability of large cDNA datasets make it feasible to find new genetic variants. In this study, we focused to perform micro array differential analysis of breast cancer dataset to reveal genetic mutants of th...
Molecular Characterization Using gtf Gene Detection and Medium Optimization of Beta-D-Glucan Production from Pediococcus parvulus F1030 Isolated from Local Egyptian Boza
Background: Lactic acid bacteria (LAB) have great benefits which can improve the nutritional value of food, reduces some infections, immune modulator effect, curbs some types of cancer and restricts glucose level of seru...
GC-MS Determination of Bioactive Constituents of the Methanolic Fractions of Cnidoscolus aconitifolius
Background: Diabetes mellitus is a major metabolic disorder affecting a huge population all over the world. Cnidoscolus species have been extensively used for the management of diabetes in folkloric medicine. The presenc...
Use of Xanthan Gum in the Formulation of Diethylcarbamazine for Targeted Drug Delivery
Matrix tablets were prepared using xanthan gum (XG) and Diethylcarbamazine was used as model drug. The controlled release of the drug by the polymer matrices in the upper gastrointestinal tract (GIT) was assessed through...
Acute and Subacute Toxicity of Sorbitan Monostearate (Span 60) Non-ionic Surfactant Vesicles (Niosomes) in Sprague Dawley Rats
This study was designed to determine the acute and subacute toxicity of non-ionic surfactant, sorbitan monostearate (Span 60) vesicles in a Sprague Dawley rat model. The primary aim was to investigate the acute toxicity...