Preparation and Controlled Drug Release Application of Mesoporous Silica Composite Microspheres
Journal Title: 河南科技大学学报（自然科学版） - Year 2017, Vol 38, Issue 2
Abstract
Mesoporous silica nanoparticles( MSNs) were synthesized by sol-gel method with triethanolamine as mild alkaline catalyst,cetyl trimethyl ammonium bromide( CTAB) as template,TEOS as silicon source. The mesoporous silica surface was modificed with a silane coupling agent 3-( methacryloxy) propyl trimethoxysilane( MPS). Mesoporous silica nanoparticles-polymethylacrylic acid( MSNs@ PMAA) composite microspheres were synthesized by precipitation polymerization method with methacrylic acid( MAA) as raw material,which exhibited obvious p H responsiveness. The structure and morphology of MSNs@ PMAA composite microspheres were characterized by small-angle X-ray powder diffraction,Fourier-transform infrared spectroscopy,transmission electron microscopy,and other characterization methods. The results show that MSNs @ PMAA composite microspheres possess long-range mesoporous channel,and their average diameter are 167 nm. The specific surface area,pore volume and pore size of MSNs are reduced from 1 081 m~2/ g,1. 756 cm~3/ g,3. 2 nm to 506 m~2/ g,1. 340 cm~3/ g,1. 7 nm,respectively. By using doxorubicin( DOX) as a model drug,MSNs @PMAA composite microspheres show higher drug loading rate,encapsulation efficiency and obvious p H responsiveness in vitro.
Authors and Affiliations
Linping ZHENG, Guangyu XU, Yingying SHI, Shiyong SONG, Puyu ZHANG
Keywords
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