PREPARATION AND EVALUATION OF IMIQUIMOD LOADED SOLID LIPID NANOPARTICLES BASED TOPICAL GEL FORMULATION: PART-I
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 3
Abstract
Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research as well as in other varied sciences. Due to their unique size-dependent properties, lipid nanoparticles offer the possibility to develop new therapeutics. The aim of the study was to prepare lipidic nanoparticles by solvent diffusion evaporation method and to study their physicochemical stability. Apifil®, Precirol® ATO 5 and Dynasan® 116 were selected as lipid. Nanoparticles with good stability and controlled particle size were obtained with Precirol® ATO 5, while it was difficult to obtain stable systems with other. Moreover other parameters like organic phase, organic solvent, concentration of Tween 20, temperature for secondary phase and drug:lipid ratio were optimized. Also systems were characterized by particle size, zeta potential, differential scanning calorimetry (DSC), Transmission Electron Microscopy (TEM), Fourier Transform Infrared Spectroscopy (FTIR) study, % entrapment efficiency and In vitro drug release study of SLN dispersion. It is appropriately investigated that solid lipid nanoparticles may open new vistas in therapy of complex diseases.
Authors and Affiliations
Mr. Tanmay N. Patel*| Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Dr. Madhabhai M. Patel| Shankersinh Vaghela Bapu Institute of Pharmacy, Gujarat Technological University
Keywords
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