PREPARATION AND EVALUATION OF IMIQUIMOD LOADED SOLID LIPID NANOPARTICLES BASED TOPICAL GEL FORMULATION: PART-I
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 3
Abstract
Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research as well as in other varied sciences. Due to their unique size-dependent properties, lipid nanoparticles offer the possibility to develop new therapeutics. The aim of the study was to prepare lipidic nanoparticles by solvent diffusion evaporation method and to study their physicochemical stability. Apifil®, Precirol® ATO 5 and Dynasan® 116 were selected as lipid. Nanoparticles with good stability and controlled particle size were obtained with Precirol® ATO 5, while it was difficult to obtain stable systems with other. Moreover other parameters like organic phase, organic solvent, concentration of Tween 20, temperature for secondary phase and drug:lipid ratio were optimized. Also systems were characterized by particle size, zeta potential, differential scanning calorimetry (DSC), Transmission Electron Microscopy (TEM), Fourier Transform Infrared Spectroscopy (FTIR) study, % entrapment efficiency and In vitro drug release study of SLN dispersion. It is appropriately investigated that solid lipid nanoparticles may open new vistas in therapy of complex diseases.
Authors and Affiliations
Mr. Tanmay N. Patel*| Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Dr. Madhabhai M. Patel| Shankersinh Vaghela Bapu Institute of Pharmacy, Gujarat Technological University
Keywords
Related Articles
- EP ID EP1771
- DOI -
- Views 409
- Downloads 25
EFFECT OF MOMORDICA CHARANTIA L. SEEDS EXTRACT ON BIOPHYSICAL AND BIOCHEMICAL PARAMETERS OF WOUND IN EXPERIMENTALLY INDUCED DIABETES IN RATS
Momordica charantia Linn. seed extrat in the form of an ointment (20% w/w dried powder in simple ointment base) was evaluated for wound-healing potential in an excision wound model whereas the the seed extract given or...
DRUG UTILIZATION EVALUATION OF THIRD GENERATION CEPHALOSPORINS IN A TERTIARY CARE HOSPITAL
Title: Study on drug utilization evaluation of third generation cephalosporins in tertiary care hospital. Objective: To evaluate prescribing pattern, to identify most common infection treated with third generation cephal...
SOLUBILITY ENHANCEMENT OF LERCANIDIPINE HYDROCHLORIDE BY COCRYSTALLISATION.
In this study, the significant effect of malonic acid on enhancement of solubility of lercanidipine hydrochloride by simple solvent change process has been demonstrated. Malonic acid and lercanidipine hydrochloride were...
CRYSTAL ENGINEERING OF NABUMETONE BY COCRYSTALLIZATION
Pharmaceutical cocrystals are multi-component solid-state assemblies of two or more compounds held together by any type or combination of intermolecular interactions. The objective of this study was to investigate the u...
EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC SEED EXTRACT Cicer arietinum AGAINST CCL4 INDUCED HEPATOTOXICITY ALBINO RATS
The present study was conducted to evaluate the hepatoprotective activity of ethanolic extract of Cicer arietinum seeds against CCl4 induced albino rats. The ethanolic extract of Cicer arietinum was administered orally...