PREPARATION AND EVALUATION OF LORNOXICAM NIOSOMAL GEL
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
The purpose of contemporary study was to project nonionic surfactant vesicles having Lornoxicam with different spans. The vesicles known as niosomes with a minor particle size and good sphericity were prepared by thin film hydration method. Lornoxicam niosomes were analyzed for their morphological aspects, vesicle size and drug entrapment efficiency. Transdermal permeation of Lornoxicam through rat abdominal skin was determined by Franz diffusion cell. The in-vitro permeation profile of optimized formulation was compared with that of Lornoxicam solution. Superior CAP/cm2 (8.57) was observed in span 60(1:1) niosomes. Further stability studies were carried out at 4ºC for a period of 8 weeks. The results of physicochemical characterization and in-vitro permeation studies of the prepared vesicles were promising to formulate transdermal drug delivery system.
Authors and Affiliations
Kapil Singla , Rekha Rao , Vipin Saini
Keywords
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