Preparation and In-Vitro Evaluation of Novel Orally Disintegrating Tablet of Clonazepam Containing Extracted Starch as Natural Disintegrant
Journal Title: International Journal of Pharma Research and Health Sciences - Year 2017, Vol 5, Issue 3
Abstract
In this present investigation , oral disintegrating tablets(ODT) of clonazepam were prepared by direct compression method with a view to enhance patient compliance. In addition to it, starch obtained from different natural sources like oats,barley,millets,wheat etc are used as a natural disintegrant to minimize the adverse affects. Five formulations were designed and The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, dispersion time and in vitro drug release. FTIR study was performed to interpret the drug ,excipient compatibility . Based on these in-vitro evaluation results, the formulation F-3 prepared by using starch obtained from oats was considered the optimal one. as it showed the maximum drug release of 99.1% in 30 minutes and showed the least wetting time 21 second and disintegration time 24second
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