PREPARATION, CHARACTERIZATION AND FORMULATION OF NANOCOMPOSITE MATRIX Na-MONTMORILLONITE INTERCALATED MEDIUM MOLECULAR WEIGHT CHITOSAN FOR THEOPHYLLINE SUSTAINED RELEASE TABLET
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 11
Abstract
Objective: The purpose of this study was to investigate Na-montmorillonite (Na-MMT) intercalated medium molecular weight (MMW) chitosan as an oral drug delivery vehicle for In Vitro release of theophylline sustained release tablet.Methods: Montmorillonite (MMT) clay were synthesized into Na-MMT and treated with chitosan. Combination becomes synthesis of Na-montmorillonite intercalated MMW chitosan. Parameters tested including MMT characterization as well as already intercalated using XRD, FTIR and SEM. Tablets were prepared using the wet granulation method. The physical properties evaluation was conducted on granules and tablets. Dissolution test used apparatus II USP model with 100 rpm of speed rotation for 6 hours and phosphate buffer pH 7.2 as a medium. Absorbance of the sample was measured on a spectrophotometer.Results: XRD spectra results showed 15.43 Ã… MMT basal spacing. Na-MMT was synthesized and distance between the layers value was 15.225 Ã…, this was because the smaller size of impurity cations than Na+ cation. After intercalation with chitosan, distance between layers became wider to 15.94Ã…. Characterization results with FTIR spectra on MMT intercalated MMW chitosan exposed similarities with Na-MMT, small shift was occurred. This indicated that intercalation with chitosan did not change the structure of Alumina silicate MMT. However, the physical properties of the granule were not affected by any difference of components formula. Tablets physical properties still meet the reference requirements. Tablets with dissolution efficiency has different values with different composition formulas.Conclusion: Characteristics of the MMT, Na-MMT, Na-MMT intercalated MMW chitosan did not change much. The intercalation process of Na-MMT with chitosan further accelerates drug release compared to MMT and exhibited a prolonged release as compared to the pure drug without MMT.Â
Authors and Affiliations
Ahmad Ainurofiq, If Nurcahyo, Rahmad Yulianto
Keywords
Related Articles
- EP ID EP579274
- DOI -
- Views 73
- Downloads 0
SYNTHESIS, EVALUATION AND DOCKING STUDIES OF NOVEL FORMAZAN DERIVATIVES AS AN ENOYL-ACP REDUCTASE INHIBITORS
Objective: To synthesize, evaluate and performing the docking studies of novel formazan derivatives as enoyl-ACP reductase inhibitors.Materials: In the present investigation, a series of formazans (Ia-d) were synthesized...
DOCKING STUDY OF ALLICIN WITH SULFONYLUREA RECEPTOR 1, COMPLEX 1 AND PPARγ RECEPTOR ON INSULIN RESISTANCE
Objective: Allicin is a potential type 2 antidiabetic. Sulfonylurea receptor 1 (SUR1), nikotinamida adina dinukleotida dehydrogenase (Complex 1) and peroxisome proliferator-activated receptors gamma (PPARγ) are known as...
PHYTOCHEMICAL EVALUATION AND IN VITRO ANTIMICROBIAL AND ANTIOXIDANT STUDIES OF LEAF AND STEM BARK EXTRACTS OF POLYALTHIA FRAGRANS (DALZ.) BEDD.–AN ENDEMIC SPECIES OF WESTERN GHATS
Objective: Phytochemical constituents of various solvent extracts of leaf and stem bark of Polyalthia fragrans (Dalz.) Bedd were screened. Antimicrobial and antioxidant activities of the extracts were evaluated.Methods:...
EVALUATION OF ANTIDEPRESSANT ACTIVITY OF HERBOMINERAL FORMULATION
Objective: In the search for new therapeutic products for the treatment of neurological disorders, medicinal plant research, worldwide, has constantly progressed, demonstrating the pharmacological effectiveness of differ...
INVESTIGATION OF CYP1A INTERACTION POTENTIAL OF WITHANIA SOMNIFERA IN RAT AND HUMAN LIVER MICROSOMES
Objective: The aim of this study was to investigate CYP1A interaction of crude extracts (ethanolic, methanolic, hydromethanolic & aqueous) of Withania somnifera and its principal phytoconstituents (withaferin-A and w...